Cyclic AMP enhances the sexual agglutinability of Chlamydomonas flagella.

U. W. Goodenough

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Sexual adhesion between Chlamydomonas reinhardtii gametes elicits a rise in intracellular cAMP levels, and exogenous elevation of intracellular cAMP levels in gametes of a single mating type induces such mating responses as cell wall loss, flagellar tip activation, and mating structure activation (Pasquale, S. M., and U. W. Goodenough. 1987. J. Cell Biol. 105:2279-2292). Here evidence is presented that sexual adhesion mobilizes agglutinin to the flagellar surface, and that this mobilization can be induced by exogenous presentation of cAMP to gametes of a single mating type. It is proposed that Chlamydomonas adhesion entails a positive feedback system--initial contacts stimulate the presentation of additional agglutinin--and that this feedback is mediated by adhesion-induced cAMP generation.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalJournal of Cell Biology
Volume109
Issue number1
DOIs
StatePublished - Jul 1989
Externally publishedYes

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