Cycle control with a 21-day compared with a 24-day oral contraceptive pill: A randomized controlled trial

Andrew M. Kaunitz, Ronald T. Burkman, Alan C. Fisher, Katherine D. Laguardia

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

OBJECTIVE: To compare bleeding patterns between a 21/7-day triphasic norgestimate/ethinyl estradiol (E2) 25-microgram oral contraceptive pill (OCP) and a 24/4-day drospirenone/ethinyl E2 20-microgram OCP. METHODS: In a three-cycle, open-label, multicenter study, healthy, sexually active women were assigned randomly to a 21/7-day (norgestimate/ethinyl E2) or 24/4-day (drospirenone/ethinyl E2) OCP regimen. Randomization was stratified to assure a balanced distribution between regimens for "fresh starts" and "switchers." Bleeding data were collected daily using an interactive voice-response system. Bleeding was defined according to the 2007 U.S. Food and Drug Administration's Reproductive Health Drug Advisory Committee-endorsed criteria. RESULTS: Across the three cycles, the 21/7-day OCP group (n=165) reported fewer unscheduled bleeding days than did the 24/4-day OCP group (n=167) (mean 4.6 compared with 6.1 days, P=.003). Women using the 21/7-day OCP had significantly fewer episodes of unscheduled bleeding than did those using the 24/4-day OCP (mean 1.47 compared with 2.01, P=.001). Moreover, women using the 21/7-day OCP had a significantly lower absence of scheduled bleeding at each cycle (P<.001). Both regimens were well-tolerated. CONCLUSION: A 21-day norgestimate/ethinyl E2 25-microgram regimen results in less unscheduled bleeding and more scheduled bleeding than does a 24-day drospirenone/ethinyl E2 20-microgram regimen.

Original languageEnglish
Pages (from-to)1205-1212
Number of pages8
JournalObstetrics and Gynecology
Volume114
Issue number6
DOIs
StatePublished - Dec 2009

Fingerprint

Dive into the research topics of 'Cycle control with a 21-day compared with a 24-day oral contraceptive pill: A randomized controlled trial'. Together they form a unique fingerprint.

Cite this