Cutting edge: CD28 controls dominant regulatory T cell activity during active immunization

Clay Lyddane, Beata U. Gajewska, Elmer Santos, Philip D. King, Glaucia C. Furtado, Michel Sadelain

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Ligation of CD28 during Ag recognition plays an important role in the generation of effective T cell responses. However, its peripheral control of regulatory T cell function remains obscure. In this study, we show that naive wild-type or CD28-/- CD4+CD25- T cells exposed to peptide in vivo develop regulatory activity that suppresses the response of adoptively transferred naive T cells to a subsequent immunogenic challenge. We find that although CD28 is engaged during the initial peptide-priming event and is essential to sustain T cell survival, it is not sufficient to prevent the dominance of regulatory T cell function. Immunization with adjuvant abrogates regulatory dominance, reducing overall Foxp3 expression in a CD28-dependent manner. We conclude that CD28 licenses active immunization by regulating Ag-induced immunoregulation.

Original languageEnglish
Pages (from-to)3305-3310
Number of pages6
JournalJournal of Immunology
Volume176
Issue number6
DOIs
StatePublished - 15 Mar 2006

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