Cutaneous nocardiosis complicating management of Crohn's disease with infliximab and prednisone

Sheldon M. Singh; Neil V. Rau; Lawrence B. Cohen; Howard Harris

doi:10.1503/cmaj.1040563

Cutaneous nocardiosis complicating management of Crohn's disease with infliximab and prednisone

Sheldon M. Singh, Neil V. Rau, Lawrence B. Cohen, Howard Harris

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51 Scopus citations

Abstract

INFLIXIMAB is A CHIMERIC ANTI-TUMOUR NECROSIS FACTOR-α antibody that is efficacious in treating Crohn's disease. However, its immunomodulatory properties increase susceptibility to opportunistic infections. We present a case of cutaneous Nocardia infection in a patient who was taking infliximab for Crohn's disease. The case illustrates the challenges in the diagnosis and management of this disease and serves as a reminder of the complications associated with the use of immunomodulatory agents.

Original language	English
Pages (from-to)	1063-1064
Number of pages	2
Journal	CMAJ
Volume	171
Issue number	9
DOIs	https://doi.org/10.1503/cmaj.1040563
State	Published - 26 Oct 2004
Externally published	Yes

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abstract = "INFLIXIMAB is A CHIMERIC ANTI-TUMOUR NECROSIS FACTOR-α antibody that is efficacious in treating Crohn's disease. However, its immunomodulatory properties increase susceptibility to opportunistic infections. We present a case of cutaneous Nocardia infection in a patient who was taking infliximab for Crohn's disease. The case illustrates the challenges in the diagnosis and management of this disease and serves as a reminder of the complications associated with the use of immunomodulatory agents.",

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AU - Singh, Sheldon M.

AU - Rau, Neil V.

AU - Cohen, Lawrence B.

AU - Harris, Howard

PY - 2004/10/26

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AB - INFLIXIMAB is A CHIMERIC ANTI-TUMOUR NECROSIS FACTOR-α antibody that is efficacious in treating Crohn's disease. However, its immunomodulatory properties increase susceptibility to opportunistic infections. We present a case of cutaneous Nocardia infection in a patient who was taking infliximab for Crohn's disease. The case illustrates the challenges in the diagnosis and management of this disease and serves as a reminder of the complications associated with the use of immunomodulatory agents.

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DO - 10.1503/cmaj.1040563

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SP - 1063

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JO - CMAJ

JF - CMAJ

IS - 9

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Cutaneous nocardiosis complicating management of Crohn's disease with infliximab and prednisone

Abstract

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