Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series

Alireza Badirzadeh; Mehdi Mohebali; Mehrdad Ghasemian; Hassan Amini; Zabiholah Zarei; Behnaz Akhoundi; Homa Hajjaran; Dariush Emdadi; Soheila Molaei; Ahmad Kusha; Saber Alizadeh

doi:10.1179/2047773213Y.0000000097

Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series

Alireza Badirzadeh, Mehdi Mohebali, Mehrdad Ghasemian, Hassan Amini, Zabiholah Zarei, Behnaz Akhoundi, Homa Hajjaran, Dariush Emdadi, Soheila Molaei, Ahmad Kusha, Saber Alizadeh

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49 Scopus citations

Abstract

Visceral leishmaniasis (VL) is endemic in Northwest and southern Iran. Reports of cutaneous leishmaniasis (CL) in Northwest areas are rare, and its etiological agents are unknown. In the current study, we report six CL and two post kala-azar dermal leishmaniasis (PKDL) cases caused by Leishmania infantum from endemic areas of VL in the Northwest. Smears were made from skin lesions of 30 suspected patients in 2002-2011, and CL was determined by microscopy or culture. Leishmania spp. were identified by nested-PCR assay. The disease was confirmed in 20 out of 30 (66%) suspected patients by parasitological examinations. L. infantum was identified in eight and Leishmania major in 12 CL cases by nested-PCR. Cutaneous leishmaniasis patients infected with L. major had the history of travel to CL endemic areas. L. infantum antibodies were detected by direct agglutination test (DAT) at titers of 1:3200 in two cases with history of VL. Results of this study indicated that L. infantum is a causative agent of CL as well as PKDL in the VL endemic areas.

Original language	English
Pages (from-to)	194-197
Number of pages	4
Journal	Pathogens and Global Health
Volume	107
Issue number	4
DOIs	https://doi.org/10.1179/2047773213Y.0000000097
State	Published - Jun 2013
Externally published	Yes

Keywords

Cutaneous leishmaniasis
Iran
Leishmania infantum
Nested-PCR
Post kala-azar dermal leishmaniasis
Visceral leishmaniasis

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Badirzadeh, A., Mohebali, M., Ghasemian, M., Amini, H., Zarei, Z., Akhoundi, B., Hajjaran, H., Emdadi, D., Molaei, S., Kusha, A., & Alizadeh, S. (2013). Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series. Pathogens and Global Health, 107(4), 194-197. https://doi.org/10.1179/2047773213Y.0000000097

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title = "Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series",

abstract = "Visceral leishmaniasis (VL) is endemic in Northwest and southern Iran. Reports of cutaneous leishmaniasis (CL) in Northwest areas are rare, and its etiological agents are unknown. In the current study, we report six CL and two post kala-azar dermal leishmaniasis (PKDL) cases caused by Leishmania infantum from endemic areas of VL in the Northwest. Smears were made from skin lesions of 30 suspected patients in 2002-2011, and CL was determined by microscopy or culture. Leishmania spp. were identified by nested-PCR assay. The disease was confirmed in 20 out of 30 (66%) suspected patients by parasitological examinations. L. infantum was identified in eight and Leishmania major in 12 CL cases by nested-PCR. Cutaneous leishmaniasis patients infected with L. major had the history of travel to CL endemic areas. L. infantum antibodies were detected by direct agglutination test (DAT) at titers of 1:3200 in two cases with history of VL. Results of this study indicated that L. infantum is a causative agent of CL as well as PKDL in the VL endemic areas.",

keywords = "Cutaneous leishmaniasis, Iran, Leishmania infantum, Nested-PCR, Post kala-azar dermal leishmaniasis, Visceral leishmaniasis",

author = "Alireza Badirzadeh and Mehdi Mohebali and Mehrdad Ghasemian and Hassan Amini and Zabiholah Zarei and Behnaz Akhoundi and Homa Hajjaran and Dariush Emdadi and Soheila Molaei and Ahmad Kusha and Saber Alizadeh",

year = "2013",

month = jun,

doi = "10.1179/2047773213Y.0000000097",

language = "English",

volume = "107",

pages = "194--197",

journal = "Pathogens and Global Health",

issn = "2047-7724",

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Badirzadeh, A, Mohebali, M, Ghasemian, M, Amini, H, Zarei, Z, Akhoundi, B, Hajjaran, H, Emdadi, D, Molaei, S, Kusha, A & Alizadeh, S 2013, 'Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series', Pathogens and Global Health, vol. 107, no. 4, pp. 194-197. https://doi.org/10.1179/2047773213Y.0000000097

Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series. / Badirzadeh, Alireza; Mohebali, Mehdi; Ghasemian, Mehrdad et al.
In: Pathogens and Global Health, Vol. 107, No. 4, 06.2013, p. 194-197.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011

T2 - A case series

AU - Badirzadeh, Alireza

AU - Mohebali, Mehdi

AU - Ghasemian, Mehrdad

AU - Amini, Hassan

AU - Zarei, Zabiholah

AU - Akhoundi, Behnaz

AU - Hajjaran, Homa

AU - Emdadi, Dariush

AU - Molaei, Soheila

AU - Kusha, Ahmad

AU - Alizadeh, Saber

PY - 2013/6

Y1 - 2013/6

N2 - Visceral leishmaniasis (VL) is endemic in Northwest and southern Iran. Reports of cutaneous leishmaniasis (CL) in Northwest areas are rare, and its etiological agents are unknown. In the current study, we report six CL and two post kala-azar dermal leishmaniasis (PKDL) cases caused by Leishmania infantum from endemic areas of VL in the Northwest. Smears were made from skin lesions of 30 suspected patients in 2002-2011, and CL was determined by microscopy or culture. Leishmania spp. were identified by nested-PCR assay. The disease was confirmed in 20 out of 30 (66%) suspected patients by parasitological examinations. L. infantum was identified in eight and Leishmania major in 12 CL cases by nested-PCR. Cutaneous leishmaniasis patients infected with L. major had the history of travel to CL endemic areas. L. infantum antibodies were detected by direct agglutination test (DAT) at titers of 1:3200 in two cases with history of VL. Results of this study indicated that L. infantum is a causative agent of CL as well as PKDL in the VL endemic areas.

AB - Visceral leishmaniasis (VL) is endemic in Northwest and southern Iran. Reports of cutaneous leishmaniasis (CL) in Northwest areas are rare, and its etiological agents are unknown. In the current study, we report six CL and two post kala-azar dermal leishmaniasis (PKDL) cases caused by Leishmania infantum from endemic areas of VL in the Northwest. Smears were made from skin lesions of 30 suspected patients in 2002-2011, and CL was determined by microscopy or culture. Leishmania spp. were identified by nested-PCR assay. The disease was confirmed in 20 out of 30 (66%) suspected patients by parasitological examinations. L. infantum was identified in eight and Leishmania major in 12 CL cases by nested-PCR. Cutaneous leishmaniasis patients infected with L. major had the history of travel to CL endemic areas. L. infantum antibodies were detected by direct agglutination test (DAT) at titers of 1:3200 in two cases with history of VL. Results of this study indicated that L. infantum is a causative agent of CL as well as PKDL in the VL endemic areas.

KW - Cutaneous leishmaniasis

KW - Iran

KW - Leishmania infantum

KW - Nested-PCR

KW - Post kala-azar dermal leishmaniasis

KW - Visceral leishmaniasis

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U2 - 10.1179/2047773213Y.0000000097

DO - 10.1179/2047773213Y.0000000097

M3 - Article

C2 - 23816511

AN - SCOPUS:84879541076

SN - 2047-7724

VL - 107

SP - 194

EP - 197

JO - Pathogens and Global Health

JF - Pathogens and Global Health

IS - 4

ER -

Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011: A case series

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Keywords

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