Atherosclerosis and its thrombotic complications are responsible for over one half million deaths annually and countless other complications. The mechanism responsible for the conversion of a stable atherosclerotic lesion to a life-threatening condition is plaque rupture. The risk of plaque rupture is a function of both plaque vulnerability and extrinsic triggers. Atherosclerotic plaques tend to develop in lesion prone areas with the participation of vascular and blood-borne cells, cytokines, lipids and proteins that interact simultaneously and/or sequentially to progress into advanced plaques. Plaque disruption can be prevented by the stabilization of vulnerable plaques and by avoiding or reducing potential trigger mechanisms.
|Number of pages||7|
|Journal||Cardiovascular Risk Factors|
|State||Published - 1996|
- Plaque rupture
- Smooth muscle cells