Current views on the pathophysiology of atherosclerosis

Research output: Contribution to journalReview articlepeer-review


Atherosclerosis and its thrombotic complications are responsible for over one half million deaths annually and countless other complications. The mechanism responsible for the conversion of a stable atherosclerotic lesion to a life-threatening condition is plaque rupture. The risk of plaque rupture is a function of both plaque vulnerability and extrinsic triggers. Atherosclerotic plaques tend to develop in lesion prone areas with the participation of vascular and blood-borne cells, cytokines, lipids and proteins that interact simultaneously and/or sequentially to progress into advanced plaques. Plaque disruption can be prevented by the stabilization of vulnerable plaques and by avoiding or reducing potential trigger mechanisms.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalCardiovascular Risk Factors
Issue number6
StatePublished - 1996
Externally publishedYes


  • Endothelium
  • Lipoproteins
  • Macrophages
  • Plaque rupture
  • Smooth muscle cells
  • Thrombosis


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