Current Understanding of Moyamoya Disease (MMD) and Associated Neuropsychiatric Outcomes

Alexei Antonov, Anthony Terraciano, Muhammed Amir Essibayi, David J. Altschul, Kainaat Javed

Research output: Contribution to journalReview articlepeer-review


Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing and occlusion of the intracranial internal carotid arteries, leading to the formation of abnormal collateral vessels. MMD primarily affects the cerebrovascular system, and evidence suggests it is associated with various neuropsychiatric outcomes. This manuscript aims to provide an overview of the current understanding of MMD, including its epidemiology, pathophysiology, clinical manifestations, and diagnosis. Furthermore, it explores the emerging research on the neuropsychiatric sequelae of MMD, such as cognitive impairment, psychiatric disorders, and quality of life. The manuscript concludes with the challenges in managing MMD-related neuropsychiatric outcomes and potential avenues for future research.

Original languageEnglish
Pages (from-to)2673-2680
Number of pages8
JournalNeuropsychiatric Disease and Treatment
StatePublished - 2023
Externally publishedYes


  • cerebrovascular disorder
  • cognitive impairment
  • moyamoya disease
  • neuropsychiatric outcomes
  • psychiatric disorders


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