@article{e0ad273beb7e41c69df90b61d9849f48,
title = "Current Status of COVID-19 (Pre)Clinical Vaccine Development",
abstract = "The current COVID-19 pandemic has a tremendous impact on daily life world-wide. Despite the ability to dampen the spread of SARS-CoV-2, the causative agent of the diseases, through restrictive interventions, it is believed that only effective vaccines will provide sufficient control over the disease and revert societal live back to normal. At present, a double-digit number of efforts are devoted to the development of a vaccine against COVID-19. Here, we provide an overview of these (pre)clinical efforts and provide background information on the technologies behind these vaccines. In addition, we discuss potential hurdles that need to be addressed prior to mass scale clinical translation of successful vaccine candidates.",
keywords = "COVID-19, SARS-CoV-2, pandemic, vaccine",
author = "Tingting Ye and Zifu Zhong and Adolfo Garc{\'i}a-Sastre and Michael Schotsaert and {De Geest}, {Bruno G.}",
note = "Funding Information: T.T. acknowledges the CSC for funding (grant N 201906320081). M.S. acknowledges the NIH/NIAID (grant N 1R21AI151229‐01). Research on COVID‐19 is supported at the A.G.S. lab by NIH supplements to grants U19AI135972, U19AI142733 and R35 HL135834, and to contract HHSN272201800048C, by a DoD supplement to grant W81XWH‐20‐1‐0270, by DARPA project HR0011‐19‐2‐0020, by CRIP (Center for Research on Influenza Pathogenesis), a NIAID funded Center of Excellence for Influenza Research and Surveillance (CEIRS, contract HHSN272201400008C), by an NIAID funded Collaborative Influenza Vaccine Innovation Center (SEM‐CIVIC, contract 75N93019C00051) and by the generous support of the JPB Foundation, the Open Philanthropy Project (research grant 2020‐215611(5384)) and anonymous donors. B.G.D.G. acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant N 817938). Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",
year = "2020",
month = oct,
day = "19",
doi = "10.1002/anie.202008319",
language = "English",
volume = "59",
pages = "18885--18897",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "43",
}