Current methods in cardiac gene therapy: Overview

Kiyotake Ishikawa, Roger J. Hajjar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations


During the last decade, there has been a significant progress toward clinical translation in the field of cardiac gene therapy based on extensive preclinical data. However, despite encouraging positive results in early phase clinical trials, more recent larger trials reported only neutral results. Nevertheless, the field has gained important knowledge from these trials and is leading to the development of more cardiotropic vectors and improved delivery systems. It has become more evident that humans are more resistant to therapeutic transgene expression compared to experimental animals and thus refinement in gene delivery tools and methods are essential for future success. We provide an overview of the current status of cardiac gene therapy focusing on gene delivery tools and methods. Newer technologies, devices, and approaches will undoubtedly lead to more promising clinical results in the near future.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages12
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Adeno-associated vectors
  • Cardiac gene therapy
  • Cardiotropic
  • Gene delivery
  • Heart failure
  • Percutaneous delivery
  • Promoters
  • Surgical delivery


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