Current and potential future drug therapies for tension-type headache

Sait Ashina, Messoud Ashina

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Tension-type headache is a common primary headache with tremendous socioeconomic impact. Establishment of an accurate diagnosis is important before initiation of any pharmacologic therapy. Simple analgesics and nonsteroidal anti-inflammatory drugs are the mainstays of treatment of episodic tension-type headache. The tricyclic antidepressant amitriptyline is the drug of choice in the preventive treatment of chronic tension-type headache. Progress in basic neuroscience has emphasized the importance of nitric oxide inhibition and N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic acid receptor antagonism in the treatment of chronic pain. It has been demonstrated that inhibition of nitric oxide is effective in chronic tension-type headache. These interesting data indicate that more specific and effective treatment possibilities will emerge in the future.

Original languageEnglish
Pages (from-to)466-474
Number of pages9
JournalCurrent Pain and Headache Reports
Issue number6
StatePublished - Dec 2003
Externally publishedYes


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