TY - JOUR
T1 - CTdatabase
T2 - A knowledge-base of high-throughput and curated data on cancer-testis antigens
AU - Almeida, Luiz Gonzaga
AU - Sakabe, Noboru J.
AU - de Oliveira, Alice R.
AU - Silva, Maria Cristina C.
AU - Mundstein, Alex S.
AU - Cohen, Tzeela
AU - Chen, Yao Tseng
AU - Chua, Ramon
AU - Gurung, Sita
AU - Gnjatic, Sacha
AU - Jungbluth, Achim A.
AU - Caballero, Otávia L.
AU - Bairoch, Amos
AU - Kiesler, Eva
AU - White, Sarah L.
AU - Simpson, Andrew J.G.
AU - Old, Lloyd J.
AU - Camargo, Anamaria A.
AU - Vasconcelos, Ana Tereza R.
N1 - Funding Information:
Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenac¸ ão de Aperfeic¸ oamento de Pessoal de Nível Superior; Fundac¸ ão Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro. Funding for open access charges: Ludwig Institute for Cancer Research.
PY - 2009
Y1 - 2009
N2 - The potency of the immune response has still to be harnessed effectively to combat human cancers. However, the discovery of T-cell targets in melanomas and other tumors has raised the possibility that cancer vaccines can be used to induce a therapeutically effective immune response against cancer. The targets, cancer-testis (CT) antigens, are immunogenic proteins preferentially expressed in normal gametogenic tissues and different histological types of tumors. Therapeutic cancer vaccines directed against CT antigens are currently in late-stage clinical trials testing whether they can delay or prevent recurrence of lung cancer and melanoma following surgical removal of primary tumors. CT antigens constitute a large, but ill-defined, family of proteins that exhibit a remarkably restricted expression. Currently, there is a considerable amount of information about these proteins, but the data are scattered through the literature and in several bioinformatic databases. The database presented here, CTdatabase (http://www.w3.org/ 1999/), unifies this knowledge to facilitate both the mining of the existing deluge of data, and the identification of proteins alleged to be CT antigens, but that do not have their characteristic restricted expression pattern. CTdatabase is more than a repository of CT antigen data, since all the available information was carefully curated and annotated with most data being specifically processed for CT antigens and stored locally. Starting from a compilation of known CT antigens, CTdatabase provides basic information including gene names and aliases, RefSeq accession numbers, genomic location, known splicing variants, gene duplications and additional family members. Gene expression at the mRNA level in normal and tumor tissues has been collated from publicly available data obtained by several different technologies. Manually curated data related to mRNA and protein expression, and antigen-specific immune responses in cancer patients are also available, together with links to PubMed for relevant CT antigen articles.
AB - The potency of the immune response has still to be harnessed effectively to combat human cancers. However, the discovery of T-cell targets in melanomas and other tumors has raised the possibility that cancer vaccines can be used to induce a therapeutically effective immune response against cancer. The targets, cancer-testis (CT) antigens, are immunogenic proteins preferentially expressed in normal gametogenic tissues and different histological types of tumors. Therapeutic cancer vaccines directed against CT antigens are currently in late-stage clinical trials testing whether they can delay or prevent recurrence of lung cancer and melanoma following surgical removal of primary tumors. CT antigens constitute a large, but ill-defined, family of proteins that exhibit a remarkably restricted expression. Currently, there is a considerable amount of information about these proteins, but the data are scattered through the literature and in several bioinformatic databases. The database presented here, CTdatabase (http://www.w3.org/ 1999/), unifies this knowledge to facilitate both the mining of the existing deluge of data, and the identification of proteins alleged to be CT antigens, but that do not have their characteristic restricted expression pattern. CTdatabase is more than a repository of CT antigen data, since all the available information was carefully curated and annotated with most data being specifically processed for CT antigens and stored locally. Starting from a compilation of known CT antigens, CTdatabase provides basic information including gene names and aliases, RefSeq accession numbers, genomic location, known splicing variants, gene duplications and additional family members. Gene expression at the mRNA level in normal and tumor tissues has been collated from publicly available data obtained by several different technologies. Manually curated data related to mRNA and protein expression, and antigen-specific immune responses in cancer patients are also available, together with links to PubMed for relevant CT antigen articles.
UR - https://www.scopus.com/pages/publications/58149186474
U2 - 10.1093/nar/gkn673
DO - 10.1093/nar/gkn673
M3 - Article
C2 - 18838390
AN - SCOPUS:58149186474
SN - 0305-1048
VL - 37
SP - D816-D819
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - SUPPL. 1
ER -