CTCA for detection of significant coronary artery disease in routine TAVI work-up: A systematic review and meta-analysis

T. P.W. van den Boogert, J. Vendrik, B. E.P.M. Claessen, J. Baan, M. A. Beijk, J. Limpens, S. A.M. Boekholdt, R. Hoek, R. N. Planken, J. P. Henriques

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Transcatheter aortic valve implantation (TAVI) has evolved to standard treatment of severe aortic stenosis in patients with an intermediate to high surgical risk. Computed tomography coronary angiography (CTCA) could partially replace invasive coronary angiography to diagnose significant coronary artery disease in the work-up for TAVI. A literature search was performed in MEDLINE and EMBASE for papers comparing CTCA and coronary angiography in TAVI candidates. The primary endpoint was the diagnostic accuracy of CTCA, compared to coronary angiography, for detection of significant (>50% diameter stenosis) coronary artery disease, measured as sensitivity, specificity, positive—(PPV) and negative predictive value (NPV). Seven studies were included, with a cumulative sample size of 1,275 patients. The patient-based pooled sensitivity, specificity, PPV and NPV were 95, 65, 71 and 94% respectively. Quality assessment revealed excellent and good quality in terms of applicability and risk of bias respectively, with the main concern being patient selection. In conclusion, on the basis of a significance cut-off value of 50% diameter stenosis, CTCA provides acceptable diagnostic accuracy for the exclusion of coronary artery disease in patients referred for TAVI. Using the routinely performed preoperative computed tomography scans as a gatekeeper for coronary angiography could decrease additional coronary angiographies by 37% in this high-risk and fragile population.

Original languageEnglish
Pages (from-to)591-599
Number of pages9
JournalNetherlands Heart Journal
Issue number12
StatePublished - 1 Dec 2018
Externally publishedYes


  • Aortic stenosis
  • Computed tomography coronary angiography
  • Coronary angiography
  • Coronary artery disease
  • Diagnostic accuracy
  • Transcatheter aortic valve implantation


Dive into the research topics of 'CTCA for detection of significant coronary artery disease in routine TAVI work-up: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this