TY - JOUR
T1 - CSF somatostatin in Alzheimer's disease
AU - Serby, Michael
AU - Richardson, Stephen B.
AU - Twente, Sally
AU - Siekierski, Joanna
AU - Corwin, June
AU - Rotrosen, John
PY - 1984
Y1 - 1984
N2 - Studies have previously demonstrated low somatostatin levels in autopsy cortical tissue from Alzheimer's disease (AD) patients and low somatostatin levels in CSF obtained from subjects with dementia. We evaluated levels of this peptide in 21 non-depressed subjects, 10 with AD, 2 with Parkinson's disease (PD), and 9 with other neurological conditions. The AD patients had significantly lower mean CSF somatostatin than the "other" neurological patients (14.6±1.5 S.E.M. versus 26.7±3.2 pg/ml, p<0.005). A demented PD subject had a level in the range of the AD group, while the non-demented PD patient had a value above this range. Thus, all 11 patients with AD or PD dementia, analogous disorders, had levels below 21.8 mg/ml, while 7 of the 10 remaining patients had values above 21.8 pg/ml. Age did not explain this finding.
AB - Studies have previously demonstrated low somatostatin levels in autopsy cortical tissue from Alzheimer's disease (AD) patients and low somatostatin levels in CSF obtained from subjects with dementia. We evaluated levels of this peptide in 21 non-depressed subjects, 10 with AD, 2 with Parkinson's disease (PD), and 9 with other neurological conditions. The AD patients had significantly lower mean CSF somatostatin than the "other" neurological patients (14.6±1.5 S.E.M. versus 26.7±3.2 pg/ml, p<0.005). A demented PD subject had a level in the range of the AD group, while the non-demented PD patient had a value above this range. Thus, all 11 patients with AD or PD dementia, analogous disorders, had levels below 21.8 mg/ml, while 7 of the 10 remaining patients had values above 21.8 pg/ml. Age did not explain this finding.
KW - Alzheimer's disease
KW - Dementia
KW - Neuropeptides
KW - Parkinsonian dementia
KW - Somatostatin
UR - http://www.scopus.com/inward/record.url?scp=0021709784&partnerID=8YFLogxK
U2 - 10.1016/0197-4580(84)90061-7
DO - 10.1016/0197-4580(84)90061-7
M3 - Article
C2 - 6151123
AN - SCOPUS:0021709784
SN - 0197-4580
VL - 5
SP - 187
EP - 189
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 3
ER -