CSF homovanillic acid in schizotypal personality disorder

Larry J. Siever; Farooq Amin; Emil F. Coccaro; Robert Trestman; Jeremy Silverman; Thomas B. Horvath; Theresa R. Mahon; Peter Knott; Larry Altstiel; Michael Davidson; Kenneth L. Davis

doi:10.1176/ajp.150.1.149

CSF homovanillic acid in schizotypal personality disorder

Larry J. Siever, Farooq Amin, Emil F. Coccaro, Robert Trestman, Jeremy Silverman, Thomas B. Horvath, Theresa R. Mahon, Peter Knott, Larry Altstiel, Michael Davidson, Kenneth L. Davis

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Abstract

CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.

Original language	English
Pages (from-to)	149-151
Number of pages	3
Journal	American Journal of Psychiatry
Volume	150
Issue number	1
DOIs	https://doi.org/10.1176/ajp.150.1.149
State	Published - 1993

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title = "CSF homovanillic acid in schizotypal personality disorder",

abstract = "CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.",

author = "Siever, {Larry J.} and Farooq Amin and Coccaro, {Emil F.} and Robert Trestman and Jeremy Silverman and Horvath, {Thomas B.} and Mahon, {Theresa R.} and Peter Knott and Larry Altstiel and Michael Davidson and Davis, {Kenneth L.}",

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AU - Siever, Larry J.

AU - Amin, Farooq

AU - Coccaro, Emil F.

AU - Trestman, Robert

AU - Silverman, Jeremy

AU - Horvath, Thomas B.

AU - Mahon, Theresa R.

AU - Knott, Peter

AU - Altstiel, Larry

AU - Davidson, Michael

AU - Davis, Kenneth L.

PY - 1993

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AB - CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.

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CSF homovanillic acid in schizotypal personality disorder

Abstract

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