Crystal structure of human cathepsin K complexed with a potent inhibitor

M. E. McGrath; J. L. Klaus; M. G. Barnes; D. Bromme

doi:10.1038/nsb0297-105

Crystal structure of human cathepsin K complexed with a potent inhibitor

M. E. McGrath
, J. L. Klaus
, M. G. Barnes
, D. Bromme

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

Abstract

The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.

Original language	English
Pages (from-to)	105-109
Number of pages	5
Journal	Nature Structural Biology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1038/nsb0297-105
State	Published - 1997
Externally published	Yes

Access to Document

10.1038/nsb0297-105

Cite this

@article{a8eb5b7afdaa4270bf170ee97a648120,

title = "Crystal structure of human cathepsin K complexed with a potent inhibitor",

abstract = "The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.",

author = "McGrath, \{M. E.\} and Klaus, \{J. L.\} and Barnes, \{M. G.\} and D. Bromme",

year = "1997",

doi = "10.1038/nsb0297-105",

language = "English",

volume = "4",

pages = "105--109",

journal = "Nature Structural Biology",

issn = "1072-8368",

publisher = "Nature Research",

number = "2",

}

TY - JOUR

T1 - Crystal structure of human cathepsin K complexed with a potent inhibitor

AU - McGrath, M. E.

AU - Klaus, J. L.

AU - Barnes, M. G.

AU - Bromme, D.

PY - 1997

Y1 - 1997

N2 - The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.

AB - The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.

UR - https://www.scopus.com/pages/publications/0031030808

U2 - 10.1038/nsb0297-105

DO - 10.1038/nsb0297-105

M3 - Article

C2 - 9033587

AN - SCOPUS:0031030808

SN - 1072-8368

VL - 4

SP - 105

EP - 109

JO - Nature Structural Biology

JF - Nature Structural Biology

IS - 2

ER -

Crystal structure of human cathepsin K complexed with a potent inhibitor

Abstract

Access to Document

Fingerprint

Cite this