TY - JOUR
T1 - Crystal deposition disease. Diagnosis by electron microscopy
AU - Honig, Stephen
AU - Gorevic, Peter
AU - Hoffstein, Sylvia
AU - Weissmann, Gerald
N1 - Funding Information:
by NIH Grants AM-1 1949, HL-19721 and HL-15140, and The Whitehall Foundation. Requests for reprints should be addressed to Dr. Stephen Honig, Division of Rheumatology, Department of Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016. Manuscript accepted July 26, 1976.
PY - 1977/7
Y1 - 1977/7
N2 - The diagnosis of gout and pseudogout has traditionally been established by the identification, in synovial fluid, of monosodium urate and calcium pyrophosphate dihydrate crystals with compensated polarizing light microscopy. In this paper the utility of electron microscopy in establishing these diagnoses in two cases, when the conventional means of synovial fluid analysis had failed to do so, is discussed. The application of ultrastructural analysis of synovial fluid increases diagnostic capability in the crystal deposition diseases, and it is recommended for those patients in whom the more usual studies have not established a diagnosis.
AB - The diagnosis of gout and pseudogout has traditionally been established by the identification, in synovial fluid, of monosodium urate and calcium pyrophosphate dihydrate crystals with compensated polarizing light microscopy. In this paper the utility of electron microscopy in establishing these diagnoses in two cases, when the conventional means of synovial fluid analysis had failed to do so, is discussed. The application of ultrastructural analysis of synovial fluid increases diagnostic capability in the crystal deposition diseases, and it is recommended for those patients in whom the more usual studies have not established a diagnosis.
UR - https://www.scopus.com/pages/publications/0017735744
U2 - 10.1016/0002-9343(77)90128-0
DO - 10.1016/0002-9343(77)90128-0
M3 - Article
C2 - 879190
AN - SCOPUS:0017735744
SN - 0002-9343
VL - 63
SP - 161
EP - 164
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 1
ER -