Abstract
Cryoglobulinemia is one of a group of syndromes characterized by the induction of clinical and/or laboratory abnormalities by cold. Cryoglobulins are immunoglobulins (Igs) that precipitate out of solution below core body temperatures, either as a single isotype (simple cryoglobulins) or as immune complexes in which both antibody and antigen are Igs (mixed cryoglobulins). In some instances, cryoglobulinemia may coexist with other related but usually distinct forms of cold hypersensitivity, such as Raynaud's phenomenon, cold agglutinin activity, or cold-dependent activation of complement (CDAC) (1).
Original language | English |
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Title of host publication | Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition |
Publisher | wiley |
Pages | 101-111 |
Number of pages | 11 |
ISBN (Electronic) | 9781683670773 |
ISBN (Print) | 9781555818715 |
DOIs | |
State | Published - 1 Jan 2016 |