Crush stenting in treating coronary bifurcate lesions: Paclitaxel eluting stents versus sirolimus eluting stents

Shao Liang Chen, Jun Jie Zhang, Fei Ye, Yun Dai Chen, Zhong Sheng Zhu, Song Lin, Nai Liang Tian, Zhi Zong Liu, Wei Yi Fang, Xue Wen Sun, Da Yi Hu, Tak W. Kwan

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Because no data regarding the comparison of crush stenting with paclitaxel (PES) or sirolimus eluting stents (SES) for coronary bifurcate lesions have been reported, we compared the clinical outcomes of these two types of stents. Methods: Two hundred and thirty patients with 242 bifurcate lesions were enrolled in a prospective, nonrandomized trial. Primary endpoints included myocardial infarction, cardiac death and target vessel revascularization at 8 months. Results: All patients were followed up clinically and 82% angiographically at 8 months. Final kissing balloon inflation was performed in 72% in the PES and 75% in the SES groups (P>0.05). Compared to the SES group, PES group had a higher late loss and incidence of restenosis (P=0.04) in the prebifurcation vessel segment. The postbifurcation vessel segment in the PES group had a greater late loss ((0.7±0.6) mm vs (0.3±0.4) mm, P<0.001) and higher restenosis in the side branch (25.5% vs 15.6%, P=0.04) when compared to the SES group. There was significant difference of insegment restenosis in the entire main vessel between PES and SES groups (P=0.004). Target lesion revascularization was more frequently seen in the PES group as compared to the SES group (P=0.01). There was significant difference in the accumulative MACE between these two groups (P=0.01). The survival rate free from target lesion revascularization was significantly higher in the SES group when compared to the PES group (P<0.001). Conclusion: SES is superior to PES in reducing restenosis and target lesion revascularization by 8-month follow-up after crush stenting for bifurcate lesions.

Original languageEnglish
Pages (from-to)528-533
Number of pages6
JournalChinese Medical Journal
Volume121
Issue number6
DOIs
StatePublished - 6 Apr 2008
Externally publishedYes

Keywords

  • Bifurcate lesions
  • Crush stenting
  • Drug eluting stent

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