Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

Alzheimer's Disease Genetics Consortium

doi:10.1016/j.celrep.2020.108091

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

Alzheimer's Disease Genetics Consortium

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Ouellette et al. identify Dlgap2 as a potential modifier of working memory in an aged Diversity Outbred (DO) mouse population. The cross-species significance of this finding is highlighted by the association between human DLGAP2 and Alzheimer's disease phenotypes at the variant, gene expression, and methylation levels.

Original language	English
Article number	108091
Journal	Cell Reports
Volume	32
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.108091
State	Published - 1 Sep 2020
Externally published	Yes

Keywords

Alzheimer's
Diversity Outbred
Dlgap2
GWAS
aging
cognition
genetic diversity
resilience
spines
susceptibility
translational

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10.1016/j.celrep.2020.108091

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@article{f70729d4d28e4aecbc55243219a27a64,

title = "Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia",

abstract = "Ouellette et al. identify Dlgap2 as a potential modifier of working memory in an aged Diversity Outbred (DO) mouse population. The cross-species significance of this finding is highlighted by the association between human DLGAP2 and Alzheimer's disease phenotypes at the variant, gene expression, and methylation levels.",

keywords = "Alzheimer's, Diversity Outbred, Dlgap2, GWAS, aging, cognition, genetic diversity, resilience, spines, susceptibility, translational",

author = "\{Alzheimer's Disease Genetics Consortium\} and Ouellette, \{Andrew R.\} and Neuner, \{Sarah M.\} and Logan Dumitrescu and Anderson, \{Laura C.\} and Gatti, \{Daniel M.\} and Mahoney, \{Emily R.\} and Bubier, \{Jason A.\} and Gary Churchill and Luanne Peters and Huentelman, \{Matthew J.\} and Herskowitz, \{Jeremy H.\} and Yang, \{Hyun Sik\} and Smith, \{Alexandra N.\} and Christiane Reitz and Kunkle, \{Brian W.\} and White, \{Charles C.\} and \{De Jager\}, \{Philip L.\} and Schneider, \{Julie A.\} and Bennett, \{David A.\} and Seyfried, \{Nicholas T.\} and Chesler, \{Elissa J.\} and Niran Hadad and Hohman, \{Timothy J.\} and Kaczorowski, \{Catherine C.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = sep,

day = "1",

doi = "10.1016/j.celrep.2020.108091",

language = "English",

volume = "32",

journal = "Cell Reports",

issn = "2639-1856",

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number = "9",

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TY - JOUR

T1 - Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

AU - Alzheimer's Disease Genetics Consortium

AU - Ouellette, Andrew R.

AU - Neuner, Sarah M.

AU - Dumitrescu, Logan

AU - Anderson, Laura C.

AU - Gatti, Daniel M.

AU - Mahoney, Emily R.

AU - Bubier, Jason A.

AU - Churchill, Gary

AU - Peters, Luanne

AU - Huentelman, Matthew J.

AU - Herskowitz, Jeremy H.

AU - Yang, Hyun Sik

AU - Smith, Alexandra N.

AU - Reitz, Christiane

AU - Kunkle, Brian W.

AU - White, Charles C.

AU - De Jager, Philip L.

AU - Schneider, Julie A.

AU - Bennett, David A.

AU - Seyfried, Nicholas T.

AU - Chesler, Elissa J.

AU - Hadad, Niran

AU - Hohman, Timothy J.

AU - Kaczorowski, Catherine C.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Ouellette et al. identify Dlgap2 as a potential modifier of working memory in an aged Diversity Outbred (DO) mouse population. The cross-species significance of this finding is highlighted by the association between human DLGAP2 and Alzheimer's disease phenotypes at the variant, gene expression, and methylation levels.

AB - Ouellette et al. identify Dlgap2 as a potential modifier of working memory in an aged Diversity Outbred (DO) mouse population. The cross-species significance of this finding is highlighted by the association between human DLGAP2 and Alzheimer's disease phenotypes at the variant, gene expression, and methylation levels.

KW - Alzheimer's

KW - Diversity Outbred

KW - Dlgap2

KW - GWAS

KW - aging

KW - cognition

KW - genetic diversity

KW - resilience

KW - spines

KW - susceptibility

KW - translational

UR - https://www.scopus.com/pages/publications/85090002916

U2 - 10.1016/j.celrep.2020.108091

DO - 10.1016/j.celrep.2020.108091

M3 - Article

C2 - 32877673

AN - SCOPUS:85090002916

SN - 2639-1856

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 9

M1 - 108091

ER -

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia

Abstract

Keywords

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