TY - JOUR
T1 - Cross-roads in the lung
T2 - Immune cells and tissue interactions as determinants of allergic asthma
AU - Ramakrishna, Lakshmi
AU - De Vries, Victor Christoff
AU - De Lafaille, Maria Alicia Curotto
N1 - Funding Information:
Acknowledgments MACL laboratory is funded by the Agency for Science, Technology and Research, Singapore.
PY - 2012/9
Y1 - 2012/9
N2 - Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung structural cells and the resident and migratory immune cells in the lung. Epithelial cells play a crucial role in allergic sensitization by directly influencing dendritic cells induction of tolerant or effector T cells and production of type 2 cytokines by innate immune cells. During chronic disease, the bronchial epithelium, stroma, and smooth muscle become structurally and functionally altered, contributing to the perpetuation of tissue remodeling. Thus, targeting tissue-driven pathology in addition to inflammation may increase the effectiveness of asthma treatment.
AB - Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung structural cells and the resident and migratory immune cells in the lung. Epithelial cells play a crucial role in allergic sensitization by directly influencing dendritic cells induction of tolerant or effector T cells and production of type 2 cytokines by innate immune cells. During chronic disease, the bronchial epithelium, stroma, and smooth muscle become structurally and functionally altered, contributing to the perpetuation of tissue remodeling. Thus, targeting tissue-driven pathology in addition to inflammation may increase the effectiveness of asthma treatment.
KW - Allergic asthma
KW - Allergic sensitization
KW - Chronic asthma
KW - Immune tolerance
KW - Lung remodeling
UR - http://www.scopus.com/inward/record.url?scp=84866740490&partnerID=8YFLogxK
U2 - 10.1007/s12026-012-8296-4
DO - 10.1007/s12026-012-8296-4
M3 - Article
C2 - 22447350
AN - SCOPUS:84866740490
SN - 0257-277X
VL - 53
SP - 213
EP - 228
JO - Immunologic Research
JF - Immunologic Research
IS - 1-3
ER -