Cross-reactive and cross-neutralizing activity of human mumps antibodies against a novel mumps virus from bats

Shannon M. Beaty, Raffael Nachbagauer, Ariana Hirsh, Frederic Vigant, James Duehr, Kristopher D. Azarm, Alice J. Stelfox, Thomas A. Bowden, W. Paul Duprex, Florian Krammer, Benhur Lee

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuVJL5). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuVJL5-F/HNBMV) virus and rMuVJL5 were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuVJL5 infection had cross-neutralizing activity against rMuVJL5-F/HNBMV. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalJournal of Infectious Diseases
Volume215
Issue number2
DOIs
StatePublished - 15 Jan 2017

Keywords

  • Mumps virus
  • Viral envelope proteins
  • Zoonoses
  • cross-reactive antibodies
  • neutralizing antibodies

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