Cross-primed CD8+T cells mediate graft rejection via a distinct effector pathway

Anna Valujskikh, Olivier Lantz, Susanna Celli, Polly Matzinger, Peter S. Heeger

Research output: Contribution to journalArticlepeer-review

169 Scopus citations


To prevent bystander destruction of healthy host tissues, cytotoxic CD8+ T lymphocytes are fitted with specific receptors that direct their destructive forces specifically against chosen targets. We show here, however, that anti-H-Y monospecific, H-2b-restricted MataHari CD8+ T cells reject H-2k male skin grafts, with which they cannot directly interact. Such rejection is interferon-γ-dependent and only occurs if the recipient endothelium expresses H-2b. The findings suggest an alternate indirect effector pathway that requires processing and presentation of the donor H-Y antigen by recipient endothelium and have implications for both transplantation and autoimmune disease.

Original languageEnglish
Pages (from-to)844-851
Number of pages8
JournalNature Immunology
Issue number9
StatePublished - Sep 2002
Externally publishedYes


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