Cross-presentation of cell-associated antigens by dendritic cells

M. Larsson, J. F. Fonteneau, N. Bhardwaj

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


There is a strict requirement for professional antigen-presenting cells (APCs) in the generation of immunity toward most viruses. Exogenous pathways of MHC class I-restricted antigen presentation play an important role in the generation of antiviral immunity, particularly in the immune surveillance of virus-infected tissues of nonhematopoietic origin, and to bypass the detrimental effects of direct virus infection on professional APCs. The mechanisms underlying generation of antiviral immunity under these circumstances are discussed.

Original languageEnglish
Pages (from-to)261-275
Number of pages15
JournalCurrent Topics in Microbiology and Immunology
StatePublished - 2003
Externally publishedYes


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