Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring

Shirley Y. Hill; Gregory Rompala; Gregg E. Homanics; Nicholas Zezza

doi:10.2217/epi-2017-0052

Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring

Shirley Y. Hill
, Gregory Rompala
, Gregg E. Homanics
, Nicholas Zezza

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Aim: We hypothesized that cross-generational effects of alcohol exposure could alter DNA methylation and expression of the HRAS oncogene and TP53 tumor suppressor gene that drive cancer development. Methods: DNA methylation of the HRAS and TP53 genes was tested in samples from young participants (Mean age of 13.4 years). Results: Controlling for both personal use and maternal use of substances during pregnancy, familial alcohol dependence was associated with hypomethylation of CpG sites in the HRAS promoter region and hypermethylation of the TP53 gene. Conclusion: The results suggest that ancestral exposure to alcohol can have enduring effects that impact epigenetic processes such as DNA methylation that controls expression of genes that drive cancer development such as HRAS and TP53.

Original language	English
Pages (from-to)	1189-1203
Number of pages	15
Journal	Epigenomics
Volume	9
Issue number	9
DOIs	https://doi.org/10.2217/epi-2017-0052
State	Published - Sep 2017
Externally published	Yes

Keywords

HRAS
TP53
alcohol dependence

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title = "Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring",

abstract = "Aim: We hypothesized that cross-generational effects of alcohol exposure could alter DNA methylation and expression of the HRAS oncogene and TP53 tumor suppressor gene that drive cancer development. Methods: DNA methylation of the HRAS and TP53 genes was tested in samples from young participants (Mean age of 13.4 years). Results: Controlling for both personal use and maternal use of substances during pregnancy, familial alcohol dependence was associated with hypomethylation of CpG sites in the HRAS promoter region and hypermethylation of the TP53 gene. Conclusion: The results suggest that ancestral exposure to alcohol can have enduring effects that impact epigenetic processes such as DNA methylation that controls expression of genes that drive cancer development such as HRAS and TP53.",

keywords = "HRAS, TP53, alcohol dependence",

author = "Hill, \{Shirley Y.\} and Gregory Rompala and Homanics, \{Gregg E.\} and Nicholas Zezza",

note = "Publisher Copyright: {\textcopyright} 2017 Shirley Y. Hill, Ph.D.",

year = "2017",

month = sep,

doi = "10.2217/epi-2017-0052",

language = "English",

volume = "9",

pages = "1189--1203",

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T1 - Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring

AU - Hill, Shirley Y.

AU - Rompala, Gregory

AU - Homanics, Gregg E.

AU - Zezza, Nicholas

PY - 2017/9

Y1 - 2017/9

N2 - Aim: We hypothesized that cross-generational effects of alcohol exposure could alter DNA methylation and expression of the HRAS oncogene and TP53 tumor suppressor gene that drive cancer development. Methods: DNA methylation of the HRAS and TP53 genes was tested in samples from young participants (Mean age of 13.4 years). Results: Controlling for both personal use and maternal use of substances during pregnancy, familial alcohol dependence was associated with hypomethylation of CpG sites in the HRAS promoter region and hypermethylation of the TP53 gene. Conclusion: The results suggest that ancestral exposure to alcohol can have enduring effects that impact epigenetic processes such as DNA methylation that controls expression of genes that drive cancer development such as HRAS and TP53.

AB - Aim: We hypothesized that cross-generational effects of alcohol exposure could alter DNA methylation and expression of the HRAS oncogene and TP53 tumor suppressor gene that drive cancer development. Methods: DNA methylation of the HRAS and TP53 genes was tested in samples from young participants (Mean age of 13.4 years). Results: Controlling for both personal use and maternal use of substances during pregnancy, familial alcohol dependence was associated with hypomethylation of CpG sites in the HRAS promoter region and hypermethylation of the TP53 gene. Conclusion: The results suggest that ancestral exposure to alcohol can have enduring effects that impact epigenetic processes such as DNA methylation that controls expression of genes that drive cancer development such as HRAS and TP53.

KW - HRAS

KW - TP53

KW - alcohol dependence

UR - https://www.scopus.com/pages/publications/85028891500

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DO - 10.2217/epi-2017-0052

M3 - Article

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AN - SCOPUS:85028891500

SN - 1750-1911

VL - 9

SP - 1189

EP - 1203

JO - Epigenomics

JF - Epigenomics

IS - 9

ER -

Cross-generational effects of alcohol dependence in humans on HRAS and TP53 methylation in offspring

Abstract

Keywords

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