Crohn's Disease: Clinical Course and Complications

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


The clinical features of Crohn's disease depend to some extent, but not exclusively, upon the anatomic location of thedisease, the severity of the inflammation and the age of the patient. Crohn's disease is best understood to be a disease of the gastrointestinal tract with protean extraintestinalmanifestations involving diverse organ systems, including the musculoskeletal system, skin, eyes, urogenital tract,cardiovascular system and neurologic system. The intestinal complications of Crohn's disease are primarily categorized as perforating complications, which includefistulas, abscesses and free perforation and cicatrizing complications (stricture). Adenocarcinoma of large and smallbowel is a rare complication of longstanding disease. Crohn's disease should be considered progressive and over long periods of observation, complicated disease behaviorsoccur in the majority of patients. However, the rate of progression of the disease is highly variable and difficult topredict for a specific individual. Clinical and subclinical features associated with complicated disease behavior include early age of onset, need fortreatment with corticosteroids, presence of serologic markers against various microbial agents and geneticpolymorphisms, including NOD2/CARD15 disease susceptibility polymorphisms.

Original languageEnglish
Title of host publicationInflammatory Bowel Disease
Subtitle of host publicationTranslating basic science into clinical practice
Number of pages17
ISBN (Print)9781405157254
StatePublished - 18 May 2010
Externally publishedYes


  • Clinical presentations - abrupt and dramatic symptoms
  • Complications, intestinal complications - "disease behavior"
  • Crohn's disease: clinical course and complications
  • Endoscopic and radiographic features
  • Natural history and prognosis - clinical course of disease activity
  • Serologic profiles - feature of Crohn's disease
  • Systems of disease classification - creating homogeneous subgroups


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