CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions

Fan Zhang, Shijia Zhao, Chunyan Ren, Yuwei Zhu, Haibin Zhou, Yongkui Lai, Fengxia Zhou, Yuqiang Jia, Kangjie Zheng, Zhiwei Huang

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

CRISPR-Cas systems not only play key roles in prokaryotic acquired immunity, but can also be adapted as powerful genome editing tools. Understanding the native role of CRISPR-Cas systems in providing adaptive immunity can lead to new CRISPR-based technologies. Here, we develop CRISPRminer, a knowledge base and web server to comprehensively collect and investigate the knowledge of CRISPR-Cas systems and generate instructive annotations, including CRISPR arrays and Cas protein annotation, CRISPR-Cas system classification, self-targeting events detection, microbe–phage interaction inference, and anti-CRISPR annotation. CRISPRminer is user-friendly and freely available at http://www.microbiome-bigdata.com/CRISPRminer.

Original languageEnglish
Article number180
JournalCommunications Biology
Volume1
Issue number1
DOIs
StatePublished - 1 Dec 2018
Externally publishedYes

Fingerprint

Dive into the research topics of 'CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions'. Together they form a unique fingerprint.

Cite this