CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells

David F. LaRosa; Andrew E. Gelman; Adeeb H. Rahman; Jidong Zhang; Laurence A. Turka; Patrick T. Walsh

doi:10.1016/j.imlet.2006.12.007

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells

David F. LaRosa, Andrew E. Gelman, Adeeb H. Rahman, Jidong Zhang, Laurence A. Turka, Patrick T. Walsh

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Toll-like receptor (TLR) ligands are notable for their ability to induce APC maturation, which in turn facilitates optimal T cell mediated immune responses. Toll-like receptor ligands, such as CpG DNA, can also modulate immune responses by blocking the suppressive effects of CD4+CD25+ regulatory T cells (Tregs). Recently, we have demonstrated that CpG DNA, in addition to its actions on APCs and Tregs, can provide direct costimulatory signals to CD4+CD25- T cells. Here we show that this costimulatory effect is sufficient to abrogate suppression by Tregs. These data indicate a previously undefined role for TLR ligands in directly modulating CD4+ T cell responses.

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	Immunology Letters
Volume	108
Issue number	2
DOIs	https://doi.org/10.1016/j.imlet.2006.12.007
State	Published - 15 Feb 2007
Externally published	Yes

Keywords

CD4+CD25+ regulatory T cells
Costimulation
CpG DNA

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title = "CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells",

abstract = "Toll-like receptor (TLR) ligands are notable for their ability to induce APC maturation, which in turn facilitates optimal T cell mediated immune responses. Toll-like receptor ligands, such as CpG DNA, can also modulate immune responses by blocking the suppressive effects of CD4+CD25+ regulatory T cells (Tregs). Recently, we have demonstrated that CpG DNA, in addition to its actions on APCs and Tregs, can provide direct costimulatory signals to CD4+CD25- T cells. Here we show that this costimulatory effect is sufficient to abrogate suppression by Tregs. These data indicate a previously undefined role for TLR ligands in directly modulating CD4+ T cell responses.",

keywords = "CD4+CD25+ regulatory T cells, Costimulation, CpG DNA",

author = "LaRosa, {David F.} and Gelman, {Andrew E.} and Rahman, {Adeeb H.} and Jidong Zhang and Turka, {Laurence A.} and Walsh, {Patrick T.}",

note = "Funding Information: This work was supported by the National Institutes of Health grant AI-43620 (to L.A.T) and by an American Society of Transplantation Basic Science Fellowship grant (to P.T.W). ",

year = "2007",

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doi = "10.1016/j.imlet.2006.12.007",

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journal = "Immunology Letters",

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T1 - CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells

AU - LaRosa, David F.

AU - Gelman, Andrew E.

AU - Rahman, Adeeb H.

AU - Zhang, Jidong

AU - Turka, Laurence A.

AU - Walsh, Patrick T.

N1 - Funding Information: This work was supported by the National Institutes of Health grant AI-43620 (to L.A.T) and by an American Society of Transplantation Basic Science Fellowship grant (to P.T.W).

PY - 2007/2/15

Y1 - 2007/2/15

N2 - Toll-like receptor (TLR) ligands are notable for their ability to induce APC maturation, which in turn facilitates optimal T cell mediated immune responses. Toll-like receptor ligands, such as CpG DNA, can also modulate immune responses by blocking the suppressive effects of CD4+CD25+ regulatory T cells (Tregs). Recently, we have demonstrated that CpG DNA, in addition to its actions on APCs and Tregs, can provide direct costimulatory signals to CD4+CD25- T cells. Here we show that this costimulatory effect is sufficient to abrogate suppression by Tregs. These data indicate a previously undefined role for TLR ligands in directly modulating CD4+ T cell responses.

AB - Toll-like receptor (TLR) ligands are notable for their ability to induce APC maturation, which in turn facilitates optimal T cell mediated immune responses. Toll-like receptor ligands, such as CpG DNA, can also modulate immune responses by blocking the suppressive effects of CD4+CD25+ regulatory T cells (Tregs). Recently, we have demonstrated that CpG DNA, in addition to its actions on APCs and Tregs, can provide direct costimulatory signals to CD4+CD25- T cells. Here we show that this costimulatory effect is sufficient to abrogate suppression by Tregs. These data indicate a previously undefined role for TLR ligands in directly modulating CD4+ T cell responses.

KW - CD4+CD25+ regulatory T cells

KW - Costimulation

KW - CpG DNA

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JO - Immunology Letters

JF - Immunology Letters

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ER -

CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells

Abstract

Keywords

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