COVID-19 and hypertension—evidence and practical management: Guidance from the HOPE Asia Network

Kazuomi Kario, Yuji Morisawa, Apichard Sukonthasarn, Yuda Turana, Yook Chin Chia, Sungha Park, Tzung Dau Wang, Chen Huan Chen, Jam Chin Tay, Yan Li, Ji Guang Wang

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


There are several risk factors for worse outcomes in patients with coronavirus 2019 disease (COVID-19). Patients with hypertension appear to have a poor prognosis, but there is no direct evidence that hypertension increases the risk of new infection or adverse outcomes independent of age and other risk factors. There is also concern about use of renin-angiotensin system (RAS) inhibitors due to a key role of angiotensin-converting enzyme 2 receptors in the entry of the SARS-CoV-2 virus into cells. However, there is little evidence that use of RAS inhibitors increases the risk of SARS-CoV-2 virus infection or worsens the course of COVID-19. Therefore, antihypertensive therapy with these agents should be continued. In addition to acute respiratory distress syndrome, patients with severe COVID-19 can develop myocardial injury and cytokine storm, resulting in heart failure, arteriovenous thrombosis, and kidney injury. Troponin, N-terminal pro-B-type natriuretic peptide, D-dimer, and serum creatinine are biomarkers for these complications and can be used to monitor patients with COVID-19 and for risk stratification. Other factors that need to be incorporated into patient management strategies during the pandemic include regular exercise to maintain good health status and monitoring of psychological well-being. For the ongoing management of patients with hypertension, telemedicine-based home blood pressure monitoring strategies can facilitate maintenance of good blood pressure control while social distancing is maintained. Overall, multidisciplinary management of COVID-19 based on a rapidly growing body of evidence will help ensure the best possible outcomes for patients, including those with risk factors such as hypertension.

Original languageEnglish
Pages (from-to)1109-1119
Number of pages11
JournalJournal of Clinical Hypertension
Issue number7
StatePublished - 1 Jul 2020
Externally publishedYes


  • COVID-19
  • angiotensin receptor blockers
  • angiotensin-converting enzyme inhibitors
  • biomarkers
  • cardiac injury
  • home blood pressure monitoring
  • hypertension
  • telemedicine


Dive into the research topics of 'COVID-19 and hypertension—evidence and practical management: Guidance from the HOPE Asia Network'. Together they form a unique fingerprint.

Cite this