Course of gentamicin nephrotoxicity

Thomas Kahn, Juan Bosch, Paul Wiener, Steven Dikman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Metabolic balance and morphologic studies were performed on rats receiving gentamicin 100 mg/kg/day for a period of 8-10 days and during the recovery period. Daily urine flow rate increased with the administration of gentamicin and remained elevated up to 20 days following the discontinuation of gentamicin, although BUN and plasma creatinine were virtually normal 10 days after the discontinuation of gentamicin. During the development of renal failure means daily electrolyte excretion remained normal. During the recovery period, however, sodium and potassium excretion exceeded control values while chloride and net acid excretion remained normal. Proteinuria developed during the administration of gentamicin and returned to normal 6-10 days after the discontinuation of gentamicin. Ten days of netilmicin administration (150 mg/kg/day) resulted in only mild tubular degeneration and no azotemia.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalToxicology
Volume16
Issue number1
DOIs
StatePublished - 1980
Externally publishedYes

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