TY - JOUR
T1 - Coupling Toll-like receptor signaling with phagocytosis
T2 - potentiation of antigen presentation
AU - Blander, J. Magarian
N1 - Funding Information:
I thank Derk Amsen and Sergio Trombetta for critical reading of the manuscript, and the Arthritis Foundation for continued support of my work.
PY - 2007/1
Y1 - 2007/1
N2 - Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed antigens by MHC class II molecules as a direct result of controlling phagosome maturation by Toll-like receptors. I discuss how the mode of antigen delivery into dendritic cells coupled with the right type of signal transduction pathway can impact greatly not only the co-stimulatory context in which the antigen is presented to naive T cells (signal 2) but MHC-II presentation of the antigen and formation of the T-cell receptor ligand (signal 1) itself.
AB - Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the presentation of antigen-derived peptides by MHC molecules occurs constitutively. Here, I highlight our new appreciation for the regulated presentation of phagocytosed antigens by MHC class II molecules as a direct result of controlling phagosome maturation by Toll-like receptors. I discuss how the mode of antigen delivery into dendritic cells coupled with the right type of signal transduction pathway can impact greatly not only the co-stimulatory context in which the antigen is presented to naive T cells (signal 2) but MHC-II presentation of the antigen and formation of the T-cell receptor ligand (signal 1) itself.
UR - http://www.scopus.com/inward/record.url?scp=33845616595&partnerID=8YFLogxK
U2 - 10.1016/j.it.2006.11.001
DO - 10.1016/j.it.2006.11.001
M3 - Article
C2 - 17126600
AN - SCOPUS:33845616595
SN - 1471-4906
VL - 28
SP - 19
EP - 25
JO - Trends in Immunology
JF - Trends in Immunology
IS - 1
ER -