Could the mechanisms of bariatric surgery hold the key for novel therapies?: Report from a Pennington Scientific Symposium

C. S. Tam; H. R. Berthoud; M. Bueter; M. V. Chakravarthy; A. Geliebter; A. Hajnal; J. Holst; L. Kaplan; W. Pories; H. Raybould; R. Seeley; A. Strader; E. Ravussin

doi:10.1111/j.1467-789X.2011.00902.x

Could the mechanisms of bariatric surgery hold the key for novel therapies? Report from a Pennington Scientific Symposium

C. S. Tam, H. R. Berthoud, M. Bueter, M. V. Chakravarthy, A. Geliebter, A. Hajnal, J. Holst, L. Kaplan, W. Pories, H. Raybould, R. Seeley, A. Strader, E. Ravussin

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Bariatric surgery is the most effective method for promoting dramatic and durable weight loss in morbidly obese subjects. Furthermore, type 2 diabetes is resolved in over 80% of patients. The mechanisms behind the amelioration in metabolic abnormalities are largely unknown but may be due to changes in energy metabolism, gut peptides and food preference. The goal of this meeting was to review the latest research to better understand the mechanisms behind the 'magic' of bariatric surgery. Replication of these effects in a non-surgical manner remains one of the ultimate challenges for the treatment of obesity and diabetes. Promising data on energy metabolism, gastrointestinal physiology, hedonic response and food intake were reviewed and discussed.

Original language	English
Pages (from-to)	984-994
Number of pages	11
Journal	Obesity Reviews
Volume	12
Issue number	11
DOIs	https://doi.org/10.1111/j.1467-789X.2011.00902.x
State	Published - Nov 2011
Externally published	Yes

Keywords

Bariatric surgery
Gut hormones
Weight loss

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Tam, C. S., Berthoud, H. R., Bueter, M., Chakravarthy, M. V., Geliebter, A., Hajnal, A., Holst, J., Kaplan, L., Pories, W., Raybould, H., Seeley, R., Strader, A., & Ravussin, E. (2011). Could the mechanisms of bariatric surgery hold the key for novel therapies? Report from a Pennington Scientific Symposium. Obesity Reviews, 12(11), 984-994. https://doi.org/10.1111/j.1467-789X.2011.00902.x

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abstract = "Bariatric surgery is the most effective method for promoting dramatic and durable weight loss in morbidly obese subjects. Furthermore, type 2 diabetes is resolved in over 80% of patients. The mechanisms behind the amelioration in metabolic abnormalities are largely unknown but may be due to changes in energy metabolism, gut peptides and food preference. The goal of this meeting was to review the latest research to better understand the mechanisms behind the 'magic' of bariatric surgery. Replication of these effects in a non-surgical manner remains one of the ultimate challenges for the treatment of obesity and diabetes. Promising data on energy metabolism, gastrointestinal physiology, hedonic response and food intake were reviewed and discussed.",

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author = "Tam, {C. S.} and Berthoud, {H. R.} and M. Bueter and Chakravarthy, {M. V.} and A. Geliebter and A. Hajnal and J. Holst and L. Kaplan and W. Pories and H. Raybould and R. Seeley and A. Strader and E. Ravussin",

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Tam, CS, Berthoud, HR, Bueter, M, Chakravarthy, MV, Geliebter, A, Hajnal, A, Holst, J, Kaplan, L, Pories, W, Raybould, H, Seeley, R, Strader, A & Ravussin, E 2011, 'Could the mechanisms of bariatric surgery hold the key for novel therapies? Report from a Pennington Scientific Symposium', Obesity Reviews, vol. 12, no. 11, pp. 984-994. https://doi.org/10.1111/j.1467-789X.2011.00902.x

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AU - Chakravarthy, M. V.

AU - Geliebter, A.

AU - Hajnal, A.

AU - Holst, J.

AU - Kaplan, L.

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Could the mechanisms of bariatric surgery hold the key for novel therapies? Report from a Pennington Scientific Symposium

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Keywords

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