Cosmetic acceptability of six 40-50% urea preparations: A single-blind, pilot study

William Stebbins, Andrew Alexis, Jacob Levitt

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Urea 40-50% is widely used in the treatment of hyperkeratotic dermatoses. Compliance with topical therapy is directly related to the esthetic and sensory acceptability of a topical agent. Objective: To assess the spreadability, odor, and post-application residue of 0.1 mL of six different urea 40-50% preparations administered in single-blind fashion to 12 trained female panelists. Methods: Spreadability was assessed at time 0, and odor and residue were assessed at 30 minutes post-application. The scores for a novel emollient preparation were compared with the composite scores of five existing preparations. Results: The novel emollient preparation was found to be the most spreadable and to leave the least residue. Odor scores were comparable and low overall. Conclusion: Urea 40-50% preparations may vary considerably in odor, spreadability, and post-application residue. The novel emollient preparation was the most cosmetically acceptable.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalAmerican Journal of Clinical Dermatology
Issue number5
StatePublished - 2008


  • Skin disorders, treatment
  • Urea compounds, therapeutic use


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