Corynanthine and Aqueous Humor Dynamics in Rabbits and Monkeys

Janet B. Serle, Arnold J. Stein, Steven M. Podos, Colette H. Severin

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The effects of corynanthine tartrate, a selective α1-adrenergic receptor antagonist, were studied on intraocular pressure by pneumatonometry, outflow facility by tonography, and aqueous humor flow by fluorophotometry in laboratory animals. Unilateral topical administration of 5% corynanthine significantly lowered mean IOP (±SEM) in rabbits for at least six hours, in ten awake monkeys for six hours, and in ten monkeys anesthetized with ketamine for four hours. The maximum effect in awake monkeys occurred two hours after drug administration, from 15.8 ± 0.5 mm Hg to 12.7 ± 0.5 mm Hg, with no substantial change in control eyes. No change in outflow facility was demonstrated in 11 monkeys two hours after 5% corynanthine administration. Aqueous humor flow rates did not change in 12 monkeys up to three hours after drug administration. Corynanthine may act by increasing uveoscleral outflow.

Original languageEnglish
Pages (from-to)1385-1388
Number of pages4
JournalArchives of Ophthalmology
Volume102
Issue number9
DOIs
StatePublished - Sep 1984

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