Cortical thinning in cingulate and occipital cortices in first episode schizophrenia

Katherine L. Narr, Arthur W. Toga, Philip Szeszko, Paul M. Thompson, Roger P. Woods, Delbert Robinson, Serge Sevy, Yung Ping Wang, Karen Schrock, Robert M. Bilder

Research output: Contribution to journalArticlepeer-review

175 Scopus citations


Background: Postmortem studies examining discrete regions show reduced cortical thickness in schizophrenia. Computational image analysis methods allow spatially detailed cortical thickness measurements across the entire cortex in 3D, but have not addressed thickness changes in cingulate or other cortices bordering the medial walls of the cerebral hemispheres in first episode schizophrenia. Methods: Magnetic resonance images and cortical pattern matching methods were used to compare gray matter thickness, measured at sub-voxel resolution at thousands of spatially equivalent locations on the medial hemispheric surfaces, between 72 (51m/21f) first episode schizophrenia patients and 78 (37m/41f) healthy controls similar in age. Group differences were mapped in 3D, and their overall significance was confirmed by permutation testing. Results: Patients with little or no prior antipsychotic medication treatment showed significant cortical thinning within cingulate, occipital and frontopolar cortices with no significant increases in any cortical location. Regional sex differences were observed with pronounced thinning in the left paracentral lobule and right posterior cingulate in male and female patients respectively compared to same sex controls. Conclusions: Cortical thinning may correspond to cytoarchitectural and neurochemical abnormalities observed in similar anatomic locations and may underlie systems-wise disturbances that include heteromodal association cortices, where cortical thinning has been previously observed in first episode schizophrenia.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalBiological Psychiatry
Issue number1
StatePublished - 1 Jul 2005
Externally publishedYes


  • Anatomy
  • Brain structure
  • Cingulate
  • Imaging
  • Limbic
  • MRI


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