@article{e3f3ae4d34c3404fab5fdc168d30f25d,
title = "Cortical Thickness Abnormalities in Cocaine Addiction-A Reflection of Both Drug Use and a Pre-existing Disposition to Drug Abuse?",
abstract = "The structural effects of cocaine on neural systems mediating cognition and motivation are not well known. By comparing the thickness of neocortical and paralimbic brain regions between cocaine-dependent and matched control subjects, we found that four of 18 a priori regions involved with executive regulation of reward and attention were significantly thinner in addicts. Correlations were significant between thinner prefrontal cortex and reduced keypresses during judgment and decision making of relative preference in addicts, suggesting one basis for restricted behavioral repertoires in drug dependence. Reduced effortful attention performance in addicts also correlated with thinner paralimbic cortices. Some thickness differences in addicts were correlated with cocaine use independent of nicotine and alcohol, but addicts also showed diminished thickness heterogeneity and altered hemispheric thickness asymmetry. These observations suggest that brain structure abnormalities in addicts are related in part to drug use and in part to predisposition toward addiction.",
keywords = "HUMDISEASE, SYSNEURO",
author = "Nikos Makris and Gasic, {Gregory P.} and Kennedy, {David N.} and Hodge, {Steven M.} and Kaiser, {Jonathan R.} and Lee, {Myung Joo} and Kim, {Byoung Woo} and Blood, {Anne J.} and Evins, {A. Eden} and Seidman, {Larry J.} and Iosifescu, {Dan V.} and Sang Lee and Claudia Baxter and Perlis, {Roy H.} and Smoller, {Jordan W.} and Maurizio Fava and Breiter, {Hans C.}",
note = "Funding Information: This work was supported by a grant to H.C.B. (#14118) from the National Institute on Drug Abuse, Bethesda, MD, and a grant (DABK39-03-C-0098; The Phenotype Genotype Project in Addiction and Depression) from the Office of National Drug Control Policy-Counterdrug Technology Assessment Center (ONDCP-CTAC), Washington, D.C. Further support, in part, was provided to H.C.B. by the MGH Department of Radiology, the National Center for Research Resources (P41RR14075), and the Mental Illness and Neuroscience Discovery Institute. Other support was provided in part by grants from the National Institutes of Health National Center for Complementary and Alternative Medicine (NCAM) to N.M. and NINDS (#34189) plus the Fairway Trust to D.N.K. ",
year = "2008",
month = oct,
day = "9",
doi = "10.1016/j.neuron.2008.08.011",
language = "English",
volume = "60",
pages = "174--188",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",
}