Correlative feature analysis of FFDM images

Yading Yuan, Maryellen L. Giger, Hui Li, Charlene Sennett

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations


Identifying the corresponding image pair of a lesion is an essential step for combining information from different views of the lesion to improve the diagnostic ability of both radiologists and CAD systems. Because of the non-rigidity of the breasts and the 2D projective property of mammograms, this task is not trivial. In this study, we present a computerized framework that differentiates the corresponding images from different views of a lesionfrom non-corresponding ones. A dual-stage segmentation method, which employs an initial radial gradient index (RGI) based segmentation and an active contour model, was initially applied to extract mass lesions from the surrounding tissues. Then various lesion features were automatically extracted from each of the two views of each lesion to quantify the characteristics of margin, shape, size, texture and context of the lesion, as well as its distance to nipple. We employed a two-step method to select an effective subset of features, and combined it with a BANN to obtain a discriminant score, which yielded an estimate of the probability that the two images are of the same physical lesion. ROC analysis was used to evaluate the performance of the individual features and the selected feature subset in the task of distinguishing between corresponding and non-corresponding pairs. By using a FFDM database with 124 corresponding image pairs and 35 non-corresponding pairs, the distance feature yielded an AUC (area under the ROC curve) of 0.8 with leave-one-out evaluation by lesion, and the feature subset, which includes distance feature, lesion size and lesion contrast, yielded an AUC of 0.86. The improvement by using multiple features was statistically significant as compared to single feature performance. (p < 0.001).

Original languageEnglish
Title of host publicationMedical Imaging 2008 - Computer-Aided Diagnosis
StatePublished - 2008
Externally publishedYes
EventMedical Imaging 2008 - Computer-Aided Diagnosis - San Diego, CA, United States
Duration: 19 Feb 200821 Feb 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2008 - Computer-Aided Diagnosis
Country/TerritoryUnited States
CitySan Diego, CA


  • Computer-aided diagnosis
  • Correlative feature analysis
  • Mammography


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