TY - JOUR
T1 - Correlation of serum IGF-I and IGFBP-1 and -3 to cardiovascular risk indicators and early carotid atherosclerosis in healthy middle-aged men
AU - Boquist, S.
AU - Ruotolo, G.
AU - Skoglund-Andersson, C.
AU - Tang, R.
AU - Björkegren, J.
AU - Bond, M. G.
AU - De Faire, U.
AU - Brismar, K.
AU - Hamsten, A.
PY - 2008/1
Y1 - 2008/1
N2 - Objectives: IGF-I, IGFBP-1 and IGFBP-3 are putative mediators in cardiovascular disease. The present study examined (i) the correlations of circulating IGF-I, IGFBP-1 and IGFBP-3 to established cardiovascular risk factors and signs of early atherosclerosis as reflected by ultrasound measurement of common carotid intima-media thickness (IMT), and (ii) whether serum concentrations of these analytes are modulated during alimentary lipaemia. Design: Cross-sectional clinical study. Patients: A biobank and clinical database based on 96 healthy Caucasian men, aged 50 years, with an apolipoprotein (apo) E3/E3 genotype, who had originally undergone investigations of postprandial lipoprotein metabolism was used for the study. Measurements: Total IGF-I, IGFBP-1 and IGFBP-3 were determined in serum by radioimmunoassay (RIA). Free IGF-I was measured by a commercial two-site immunoradiometric assay (IRMA). Results: In multivariate analyses, fasting serum free IGF-I correlated inversely with IMT and accounted for 5% of the variation in multiple R 2. When fasting serum IGFBP-1 was entered in the models instead of IGF-I, IGFBP-1 correlated positively with IMT and accounted for 6% of the variation in IMT. IGFBP-3 and total IGF-I were unrelated to IMT. There were no associations between free IGF-I and cardiovascular risk factors, whereas IGFBP-1 behaved like a component of the insulin resistance syndrome. Serum free IGF-I increased and IGFBP-1 decreased postprandially. Conclusion: The data indicate that serum free IGF-I and IGFBP-1 are implicated in early atherosclerosis.
AB - Objectives: IGF-I, IGFBP-1 and IGFBP-3 are putative mediators in cardiovascular disease. The present study examined (i) the correlations of circulating IGF-I, IGFBP-1 and IGFBP-3 to established cardiovascular risk factors and signs of early atherosclerosis as reflected by ultrasound measurement of common carotid intima-media thickness (IMT), and (ii) whether serum concentrations of these analytes are modulated during alimentary lipaemia. Design: Cross-sectional clinical study. Patients: A biobank and clinical database based on 96 healthy Caucasian men, aged 50 years, with an apolipoprotein (apo) E3/E3 genotype, who had originally undergone investigations of postprandial lipoprotein metabolism was used for the study. Measurements: Total IGF-I, IGFBP-1 and IGFBP-3 were determined in serum by radioimmunoassay (RIA). Free IGF-I was measured by a commercial two-site immunoradiometric assay (IRMA). Results: In multivariate analyses, fasting serum free IGF-I correlated inversely with IMT and accounted for 5% of the variation in multiple R 2. When fasting serum IGFBP-1 was entered in the models instead of IGF-I, IGFBP-1 correlated positively with IMT and accounted for 6% of the variation in IMT. IGFBP-3 and total IGF-I were unrelated to IMT. There were no associations between free IGF-I and cardiovascular risk factors, whereas IGFBP-1 behaved like a component of the insulin resistance syndrome. Serum free IGF-I increased and IGFBP-1 decreased postprandially. Conclusion: The data indicate that serum free IGF-I and IGFBP-1 are implicated in early atherosclerosis.
UR - http://www.scopus.com/inward/record.url?scp=36949040589&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2265.2007.02998.x
DO - 10.1111/j.1365-2265.2007.02998.x
M3 - Article
C2 - 17803702
AN - SCOPUS:36949040589
SN - 0300-0664
VL - 68
SP - 51
EP - 58
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 1
ER -