Correlation of DNA Distribution Abnormalities with Cytogenetic Findings in Human Adult Leukemia and Lymphoma

Barthel Barlogie; Gary Spitzer; Jose M. Trujillo; Jacqueline S. Hart; Leslie Smallwood; Benjamin Drewinko

Correlation of DNA Distribution Abnormalities with Cytogenetic Findings in Human Adult Leukemia and Lymphoma

Barthel Barlogie, Gary Spitzer, Jose M. Trujillo, Jacqueline S. Hart, Leslie Smallwood, Benjamin Drewinko

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112 Scopus citations

Abstract

Pulse cytophotometric analysis of bone marrow cells from 175 patients with leukemia or lymphoma showed abnormalities of cellular DNA distribution in 29 patients for an overall incidence of 16.6%. Comparative standard cytogenetic examination indicated that high-degree chromosomal aberrations (≤44, ≥53 chromosomes) can generally be detected on DNA histograms, whereas patients with diploid, pseudodiploid, 45-hypodiploid, and 47-hyperdiploid abnormalities usually escape recognition by this technique. There were 11 patients with normal diploid or neardiploid karyotypes exhibiting marked DNA deviations; this discrepancy may reflect lack of proliferation of some leukemic clones which is a prerequisite for cytogenetic identification.

Original language	English
Pages (from-to)	4400-4407
Number of pages	8
Journal	Cancer Research
Volume	37
Issue number	12
State	Published - 1 Dec 1977
Externally published	Yes

Cite this

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title = "Correlation of DNA Distribution Abnormalities with Cytogenetic Findings in Human Adult Leukemia and Lymphoma",

abstract = "Pulse cytophotometric analysis of bone marrow cells from 175 patients with leukemia or lymphoma showed abnormalities of cellular DNA distribution in 29 patients for an overall incidence of 16.6%. Comparative standard cytogenetic examination indicated that high-degree chromosomal aberrations (≤44, ≥53 chromosomes) can generally be detected on DNA histograms, whereas patients with diploid, pseudodiploid, 45-hypodiploid, and 47-hyperdiploid abnormalities usually escape recognition by this technique. There were 11 patients with normal diploid or neardiploid karyotypes exhibiting marked DNA deviations; this discrepancy may reflect lack of proliferation of some leukemic clones which is a prerequisite for cytogenetic identification.",

author = "Barthel Barlogie and Gary Spitzer and Trujillo, {Jose M.} and Hart, {Jacqueline S.} and Leslie Smallwood and Benjamin Drewinko",

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T1 - Correlation of DNA Distribution Abnormalities with Cytogenetic Findings in Human Adult Leukemia and Lymphoma

AU - Barlogie, Barthel

AU - Spitzer, Gary

AU - Trujillo, Jose M.

AU - Hart, Jacqueline S.

AU - Smallwood, Leslie

AU - Drewinko, Benjamin

PY - 1977/12/1

Y1 - 1977/12/1

N2 - Pulse cytophotometric analysis of bone marrow cells from 175 patients with leukemia or lymphoma showed abnormalities of cellular DNA distribution in 29 patients for an overall incidence of 16.6%. Comparative standard cytogenetic examination indicated that high-degree chromosomal aberrations (≤44, ≥53 chromosomes) can generally be detected on DNA histograms, whereas patients with diploid, pseudodiploid, 45-hypodiploid, and 47-hyperdiploid abnormalities usually escape recognition by this technique. There were 11 patients with normal diploid or neardiploid karyotypes exhibiting marked DNA deviations; this discrepancy may reflect lack of proliferation of some leukemic clones which is a prerequisite for cytogenetic identification.

AB - Pulse cytophotometric analysis of bone marrow cells from 175 patients with leukemia or lymphoma showed abnormalities of cellular DNA distribution in 29 patients for an overall incidence of 16.6%. Comparative standard cytogenetic examination indicated that high-degree chromosomal aberrations (≤44, ≥53 chromosomes) can generally be detected on DNA histograms, whereas patients with diploid, pseudodiploid, 45-hypodiploid, and 47-hyperdiploid abnormalities usually escape recognition by this technique. There were 11 patients with normal diploid or neardiploid karyotypes exhibiting marked DNA deviations; this discrepancy may reflect lack of proliferation of some leukemic clones which is a prerequisite for cytogenetic identification.

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M3 - Article

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SP - 4400

EP - 4407

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 12

ER -

Correlation of DNA Distribution Abnormalities with Cytogenetic Findings in Human Adult Leukemia and Lymphoma

Abstract

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