Correlation of DNA Distribution Abnormalities with Cytogenetic Findings in Human Adult Leukemia and Lymphoma

Barthel Barlogie, Gary Spitzer, Jose M. Trujillo, Jacqueline S. Hart, Leslie Smallwood, Benjamin Drewinko

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Pulse cytophotometric analysis of bone marrow cells from 175 patients with leukemia or lymphoma showed abnormalities of cellular DNA distribution in 29 patients for an overall incidence of 16.6%. Comparative standard cytogenetic examination indicated that high-degree chromosomal aberrations (≤44, ≥53 chromosomes) can generally be detected on DNA histograms, whereas patients with diploid, pseudodiploid, 45-hypodiploid, and 47-hyperdiploid abnormalities usually escape recognition by this technique. There were 11 patients with normal diploid or neardiploid karyotypes exhibiting marked DNA deviations; this discrepancy may reflect lack of proliferation of some leukemic clones which is a prerequisite for cytogenetic identification.

Original languageEnglish
Pages (from-to)4400-4407
Number of pages8
JournalCancer Research
Volume37
Issue number12
StatePublished - 1 Dec 1977
Externally publishedYes

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