Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

Jianda Yuan; David B. Page; Geoffrey Y. Ku; Yanyun Li; Zhenyu Mu; Charlotte Ariyan; Humilidad F. Gallardo; Ruth Ann Roman; Agnes I. Heine; Stephanie L. Terzulli; Sacha Gnjatic; Gerd Ritter; Achim A. Jungbluth; James P. Allison; Lloyd J. Old; Jedd D. Wolchok

Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

Jianda Yuan, David B. Page, Geoffrey Y. Ku, Yanyun Li, Zhenyu Mu, Charlotte Ariyan, Humilidad F. Gallardo, Ruth Ann Roman, Agnes I. Heine, Stephanie L. Terzulli, Sacha Gnjatic, Gerd Ritter, Achim A. Jungbluth, James P. Allison, Lloyd J. Old, Jedd D. Wolchok

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.

Original language	English
Journal	Cancer Immunity
Volume	10
State	Published - 7 Jan 2010
Externally published	Yes

Keywords

Case report
Human
Immunoediting
Immunogram
Ipilimumab
Melanoma

Cite this

Yuan, J., Page, D. B., Ku, G. Y., Li, Y., Mu, Z., Ariyan, C., Gallardo, H. F., Roman, R. A., Heine, A. I., Terzulli, S. L., Gnjatic, S., Ritter, G., Jungbluth, A. A., Allison, J. P., Old, L. J., & Wolchok, J. D. (2010). Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy. Cancer Immunity, 10.

@article{8b176a4cf4944e96b1dd60feb1e8bab8,

title = "Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy",

abstract = "Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.",

keywords = "Case report, Human, Immunoediting, Immunogram, Ipilimumab, Melanoma",

author = "Jianda Yuan and Page, {David B.} and Ku, {Geoffrey Y.} and Yanyun Li and Zhenyu Mu and Charlotte Ariyan and Gallardo, {Humilidad F.} and Roman, {Ruth Ann} and Heine, {Agnes I.} and Terzulli, {Stephanie L.} and Sacha Gnjatic and Gerd Ritter and Jungbluth, {Achim A.} and Allison, {James P.} and Old, {Lloyd J.} and Wolchok, {Jedd D.}",

year = "2010",

month = jan,

day = "7",

language = "English",

volume = "10",

journal = "Cancer Immunity",

issn = "2326-6066",

publisher = "American Association for Cancer Research Inc.",

}

TY - JOUR

T1 - Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

AU - Yuan, Jianda

AU - Page, David B.

AU - Ku, Geoffrey Y.

AU - Li, Yanyun

AU - Mu, Zhenyu

AU - Ariyan, Charlotte

AU - Gallardo, Humilidad F.

AU - Roman, Ruth Ann

AU - Heine, Agnes I.

AU - Terzulli, Stephanie L.

AU - Gnjatic, Sacha

AU - Ritter, Gerd

AU - Jungbluth, Achim A.

AU - Allison, James P.

AU - Old, Lloyd J.

AU - Wolchok, Jedd D.

PY - 2010/1/7

Y1 - 2010/1/7

N2 - Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.

AB - Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.

KW - Case report

KW - Human

KW - Immunoediting

KW - Immunogram

KW - Ipilimumab

KW - Melanoma

UR - http://www.scopus.com/inward/record.url?scp=76149137243&partnerID=8YFLogxK

M3 - Article

C2 - 20052966

AN - SCOPUS:76149137243

SN - 2326-6066

VL - 10

JO - Cancer Immunity

JF - Cancer Immunity

ER -

Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

Abstract

Keywords

Fingerprint

Cite this