Correlation between the functional assay for activated protein c resistance and factor V Leiden in the neonate

Maria T. Sifontes; Rachelle Nuss; Stephen P. Hunger; Linda J. Jacobson; Jill Waters; Marilyn J. Manco-Johnson

doi:10.1203/00006450-199712000-00009

Correlation between the functional assay for activated protein c resistance and factor V Leiden in the neonate

Maria T. Sifontes
, Rachelle Nuss
, Stephen P. Hunger
, Linda J. Jacobson
, Jill Waters
, Marilyn J. Manco-Johnson

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A factor V₅₀₆ Arg-Gln mutation is the most common inherited cause of thrombophilia in adults. To date, there are no data regarding the detection of this mutation in neonatal blood or the relationship of this dysfunctional factor V to neonatal thrombosis. This study compared a modified activated protein C resistance functional assay with the PCR-based DNA assay for the factor V mutation in 115 prospectively collected umbilical cord blood samples. The incidence of activated protein C resistance in cord blood was 6%. The sensitivity and specificity of the modified assay for the factor V Leiden mutation was 100%.

Original language	English
Pages (from-to)	776-778
Number of pages	3
Journal	Pediatric Research
Volume	42
Issue number	6
DOIs	https://doi.org/10.1203/00006450-199712000-00009
State	Published - Dec 1997
Externally published	Yes

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title = "Correlation between the functional assay for activated protein c resistance and factor V Leiden in the neonate",

abstract = "A factor V506 Arg-Gln mutation is the most common inherited cause of thrombophilia in adults. To date, there are no data regarding the detection of this mutation in neonatal blood or the relationship of this dysfunctional factor V to neonatal thrombosis. This study compared a modified activated protein C resistance functional assay with the PCR-based DNA assay for the factor V mutation in 115 prospectively collected umbilical cord blood samples. The incidence of activated protein C resistance in cord blood was 6\%. The sensitivity and specificity of the modified assay for the factor V Leiden mutation was 100\%.",

author = "Sifontes, \{Maria T.\} and Rachelle Nuss and Hunger, \{Stephen P.\} and Jacobson, \{Linda J.\} and Jill Waters and Manco-Johnson, \{Marilyn J.\}",

year = "1997",

month = dec,

doi = "10.1203/00006450-199712000-00009",

language = "English",

volume = "42",

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journal = "Pediatric Research",

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T1 - Correlation between the functional assay for activated protein c resistance and factor V Leiden in the neonate

AU - Sifontes, Maria T.

AU - Nuss, Rachelle

AU - Hunger, Stephen P.

AU - Jacobson, Linda J.

AU - Waters, Jill

AU - Manco-Johnson, Marilyn J.

PY - 1997/12

Y1 - 1997/12

N2 - A factor V506 Arg-Gln mutation is the most common inherited cause of thrombophilia in adults. To date, there are no data regarding the detection of this mutation in neonatal blood or the relationship of this dysfunctional factor V to neonatal thrombosis. This study compared a modified activated protein C resistance functional assay with the PCR-based DNA assay for the factor V mutation in 115 prospectively collected umbilical cord blood samples. The incidence of activated protein C resistance in cord blood was 6%. The sensitivity and specificity of the modified assay for the factor V Leiden mutation was 100%.

AB - A factor V506 Arg-Gln mutation is the most common inherited cause of thrombophilia in adults. To date, there are no data regarding the detection of this mutation in neonatal blood or the relationship of this dysfunctional factor V to neonatal thrombosis. This study compared a modified activated protein C resistance functional assay with the PCR-based DNA assay for the factor V mutation in 115 prospectively collected umbilical cord blood samples. The incidence of activated protein C resistance in cord blood was 6%. The sensitivity and specificity of the modified assay for the factor V Leiden mutation was 100%.

UR - https://www.scopus.com/pages/publications/0030723663

U2 - 10.1203/00006450-199712000-00009

DO - 10.1203/00006450-199712000-00009

M3 - Article

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AN - SCOPUS:0030723663

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VL - 42

SP - 776

EP - 778

JO - Pediatric Research

JF - Pediatric Research

IS - 6

ER -

Correlation between the functional assay for activated protein c resistance and factor V Leiden in the neonate

Abstract

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