Correlation between the evaluation of pigmented lesions by a multi-spectral digital skin lesion analysis device and the clinical and histological features of melanoma

Richard R. Winkelmann, Darrell S. Rigel, Laura Ferris, Arthur Sober, Natalie Tucker, Clay J. Cockerell

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: To correlate Multi-spectral Digital Skin Lesion Analysis classifier scores with histopathological severity of pigmented lesions and clinical features of melanoma. Design: Classifier scores were computed for 1,632 skin lesions. Dermatologists evaluated the same lesions for Asymmetry, Border Irregularity, Color variegation, Diameter >6mm, Evolution, Patient's Concern, Regression, and/or "Ugly Duckling" sign. Classifier scores were correlated to the number of clinical risk features and for six histopathological severity levels of pigmented lesions. Measurements: Average classifier score, Welch's t-test, and chi-square analysis. Results: Melanomas had higher mean classifier scores (3.5) than high-grade dysplastic nevi (2.7, p=0.002), low-grade dysplastic nevi (1.7, p<0.0001), non-dysplastic nevi (1.6, p<0.0001), and benign non-melanocytic lesions (2.0, p<0.0001). Classifier score and the number of clinical risk characteristics directly correlated (Pearson coefficient 0.32, p<0.0001). Conclusion: Correlation of classifier scores to clinical and histological melanoma features supports the effectiveness of Multi-spectral Digital Skin Lesion Analysis in assessing the risk of pigmented lesions requiring biopsy. Optimizing outcomes of dermatologist decisions to biopsy suspicious pigmented lesions may be enhanced utilizing Multispectral Digital Skin Lesion Analysis.

Original languageEnglish
Pages (from-to)36-38
Number of pages3
JournalJournal of Clinical and Aesthetic Dermatology
Volume9
Issue number3
StatePublished - Mar 2016
Externally publishedYes

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