Correlation between the concentration of serum anti-topoisomerase I autoantibodies and histological and biochemical alterations in the skin of tight skin mice

Akira Hatakeyama, Kuppuswamy N. Kasturi, Imrai Wolf, Robert G. Phelps, Constantin A. Bona

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Cutaneous hyperplasia observed in tight skin mice is due to a mutation located on chromosome 2. While homozygous mice die in utero the heterozygotes survive. TSK syndrome is associated with the presence of autoantibodies specific for scleroderma target autoantigens. The presence of autoantibodies specific for topoisomerase I is characteristic of both human and murine disease. We have generated two distinct genotypes of mice, TSK/+ and +/+ with respect to the TSK trait by breeding TSK mice with immunodeficient mouse strains. Since the mutated gene of TSK syndrome has not yet been cloned, only histological and biochemical criteria were used for defining TSK genotype, In the F1 mice derived by mating TSK/+ mice with RAG2-/-, J(H)-/-, or C57BL vit/vit mice, we have found a good correlation between the amount of serum anti-topoisomerase I autoantibodies present and the histopathological and biochemical alterations that are characteristic of TSK scleroderma-like syndrome.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalCellular Immunology
Volume167
Issue number1
DOIs
StatePublished - 10 Jan 1996

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