Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion

Verônica Castro Lima, Ling Yeung, Leonardo C. Castro, Gennady Landa, Richard B. Rosen

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Purpose: To investigate the relationship between spectral domain optical coherence tomography (SD-OCT) findings and visual outcomes following resolution of macular edema in central retinal vein occlusion (CRVO). Methods: Patients with recent onset CRVO who had undergone SD-OCT and fluoresceinangiography (FA) exams on the day of initial presentation were included. All patients hadre solution of macular edema in SD-OCT images at the end of follow-up, and they were separated into two groups according to final visual acuity: group 1 (≤20/200) and group 2 (<20/200). SD-OCT scans and FA studies were analyzed in a masked fashion. Macular perfusion status by FA was categorized according to presence or absence of macular ischemia. Results: A total of 22 eyes from 22 patients [mean age 53.0 ± 15.0 (standard deviation)] were included. Mean follow up period was 14.6 ± 8.1 (standard deviation) months. Group 1 (10 eyes) had significantly higher rates of residual intraretinal fluid, loss of foveal inner segment/outer segment (IS/OS) junction line and loss of inner retinal layers in late stage SD-OCT images (P = 0.027) when compared with group 2 (12 eyes). Loss of foveal IS/OS junction line (odds ratio [OR] = 13.826; P = 0.098) and loss of inner retinal layers (OR = 38.908; P = 0.013) in late stage SD-OCT images were correlated with poorer final visual outcomes. Macular ischemia by FA correlated with thinner central subfield thickness (r= -0.54, P = 0.021) and loss of inner retinal layers (r = 0.47, P = 0.031) in early stage SD-OCT images; and presence of residual intraretinal fluid (r = 0.61, P = 0.003) and loss of inner retinal layers (r = 0.71, P < 0.001) in late stage SD-OCT images. Conclusion: Loss of foveal IS/OS junction line and inner retinal layers on SD-OCT significantly correlated with poorer visual outcomes in CRVO patients.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalClinical Ophthalmology
Volume5
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Inner retinal layers
  • Macular edema
  • Macular ischemia

Fingerprint

Dive into the research topics of 'Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion'. Together they form a unique fingerprint.

Cite this