Correction to: White matter lipid alterations during aging in the rhesus monkey brain (GeroScience, (2024), 10.1007/s11357-024-01353-3)

The original version of this article unfortunately contained errors in Figures 2 and 9. Figures 2 and 9 were corrected from: Wrong Figure 2 (Figure presented.) Correct Figure 2 (Figure presented.) FIGURE 2: Global lipid components of cell membranes decrease in aged monkey white matter tracts. (A,B) Hierarchical cluster analysis from significant lipids shown in positive (A) and negative (B) ion mode, reveal that age groups are clearly classified by lipid changes. (C,D) Analysis of total lipids and adducts detected by LC-MS, revealed 409 total lipids that showed significant alterations ( -log10(p-value) ≥ 1.3), 327 from the positive ion (C) and163 from the negative ion (D). (E,F) From the same raw dataset, lipid classes that showed the highest number of altered lipids revealed relatively similar up and downregulation for the positive mode (E) while the negative mode detected more downregulated lipid species in the young group (F). (G,H) Pathway analysis of significant lipids enrichment in young white matter samples relative to old white matter samples from positive (G) and negative (H) ion modes. Wrong Figure 9 (Figure presented.) Correct Figure 9 (Figure presented.) FIGURE 9: Lipid biosynthesis enzyme expression is downregulated in aging. (A) Selective sphingolipid biosynthesis enzymes show decreased expression in aging white matter. (B) Plasmalogen biosynthesis enzyme expression was significantly decreased in aging white matter (C) Lipid elongation mediated by ELOVL1 was downregulated with age. (D) Main aspects of cholesterol synthesis and transport decreased age. (E) Graphical summary of lipid biosynthesis pathways that change in the aged monkey corpus callosum (grey: downregulated genes, green unchanged genes). (N=10, 5 young; 5 old rhesus monkeys; *p<0.05, **p<0.01, ***p<0.001).