Core/shell structured iron/iron-oxide nanoparticles as excellent MRI contrast enhancement agents

Hafsa Khurshid; Costas G. Hadjipanayis; Hongwei Chen; Wanfeng Li; Hui Mao; Revaz MacHaidze; Vasilis Tzitzios; George C. Hadjipanayis

doi:10.1016/j.jmmm.2012.10.049

Core/shell structured iron/iron-oxide nanoparticles as excellent MRI contrast enhancement agents

Hafsa Khurshid, Costas G. Hadjipanayis, Hongwei Chen, Wanfeng Li, Hui Mao, Revaz MacHaidze, Vasilis Tzitzios, George C. Hadjipanayis

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We report the use of metallic iron-based nanoparticles for magnetic resonance imaging (MRI) applications. Core/shell structured iron-based nanoparticles prepared by thermally decomposing organo-metallic compounds of iron at high temperature in the presence of hydrophobic surfactants were coated and stabilized in the aqueous solvent using the newly developed polysiloxane PEO-b-PγMPS (poly(ethylene oxide)-block-poly (γ methacryloxypropyl trimethyl oxysilane)) diblock copolymers. Particles are well suspended in water and retain their core-shell morphology after coating with the copolymer. In comparison to the conventionally used iron-oxide nanoparticles, core/shell structured iron/iron-oxide nanoparticles offer a much stronger T₂ shortening effect than that of iron-oxide with the same core size due to their better magnetic properties.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Journal of Magnetism and Magnetic Materials
Volume	331
DOIs	https://doi.org/10.1016/j.jmmm.2012.10.049
State	Published - Apr 2013
Externally published	Yes

Keywords

Core-shell nanoparticles
Iron nanoparticles
Magnetic resonance imaging

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10.1016/j.jmmm.2012.10.049

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title = "Core/shell structured iron/iron-oxide nanoparticles as excellent MRI contrast enhancement agents",

abstract = "We report the use of metallic iron-based nanoparticles for magnetic resonance imaging (MRI) applications. Core/shell structured iron-based nanoparticles prepared by thermally decomposing organo-metallic compounds of iron at high temperature in the presence of hydrophobic surfactants were coated and stabilized in the aqueous solvent using the newly developed polysiloxane PEO-b-PγMPS (poly(ethylene oxide)-block-poly (γ methacryloxypropyl trimethyl oxysilane)) diblock copolymers. Particles are well suspended in water and retain their core-shell morphology after coating with the copolymer. In comparison to the conventionally used iron-oxide nanoparticles, core/shell structured iron/iron-oxide nanoparticles offer a much stronger T2 shortening effect than that of iron-oxide with the same core size due to their better magnetic properties.",

keywords = "Core-shell nanoparticles, Iron nanoparticles, Magnetic resonance imaging",

author = "Hafsa Khurshid and Hadjipanayis, \{Costas G.\} and Hongwei Chen and Wanfeng Li and Hui Mao and Revaz MacHaidze and Vasilis Tzitzios and Hadjipanayis, \{George C.\}",

note = "Funding Information: This work was supported by NSF DMR-0302544 ",

year = "2013",

month = apr,

doi = "10.1016/j.jmmm.2012.10.049",

language = "English",

volume = "331",

pages = "17--20",

journal = "Journal of Magnetism and Magnetic Materials",

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publisher = "Elsevier B.V.",

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T1 - Core/shell structured iron/iron-oxide nanoparticles as excellent MRI contrast enhancement agents

AU - Khurshid, Hafsa

AU - Hadjipanayis, Costas G.

AU - Chen, Hongwei

AU - Li, Wanfeng

AU - Mao, Hui

AU - MacHaidze, Revaz

AU - Tzitzios, Vasilis

AU - Hadjipanayis, George C.

N1 - Funding Information: This work was supported by NSF DMR-0302544

PY - 2013/4

Y1 - 2013/4

N2 - We report the use of metallic iron-based nanoparticles for magnetic resonance imaging (MRI) applications. Core/shell structured iron-based nanoparticles prepared by thermally decomposing organo-metallic compounds of iron at high temperature in the presence of hydrophobic surfactants were coated and stabilized in the aqueous solvent using the newly developed polysiloxane PEO-b-PγMPS (poly(ethylene oxide)-block-poly (γ methacryloxypropyl trimethyl oxysilane)) diblock copolymers. Particles are well suspended in water and retain their core-shell morphology after coating with the copolymer. In comparison to the conventionally used iron-oxide nanoparticles, core/shell structured iron/iron-oxide nanoparticles offer a much stronger T2 shortening effect than that of iron-oxide with the same core size due to their better magnetic properties.

AB - We report the use of metallic iron-based nanoparticles for magnetic resonance imaging (MRI) applications. Core/shell structured iron-based nanoparticles prepared by thermally decomposing organo-metallic compounds of iron at high temperature in the presence of hydrophobic surfactants were coated and stabilized in the aqueous solvent using the newly developed polysiloxane PEO-b-PγMPS (poly(ethylene oxide)-block-poly (γ methacryloxypropyl trimethyl oxysilane)) diblock copolymers. Particles are well suspended in water and retain their core-shell morphology after coating with the copolymer. In comparison to the conventionally used iron-oxide nanoparticles, core/shell structured iron/iron-oxide nanoparticles offer a much stronger T2 shortening effect than that of iron-oxide with the same core size due to their better magnetic properties.

KW - Core-shell nanoparticles

KW - Iron nanoparticles

KW - Magnetic resonance imaging

UR - https://www.scopus.com/pages/publications/84872714141

U2 - 10.1016/j.jmmm.2012.10.049

DO - 10.1016/j.jmmm.2012.10.049

M3 - Article

AN - SCOPUS:84872714141

SN - 0304-8853

VL - 331

SP - 17

EP - 20

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

ER -

Core/shell structured iron/iron-oxide nanoparticles as excellent MRI contrast enhancement agents

Abstract

Keywords

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