Core Concepts Involving Adverse Psychotropic Drug Effects: Assessment, Implications, and Management

Joseph F. Goldberg; Carrie L. Ernst

doi:10.1016/j.psc.2016.04.001

Core Concepts Involving Adverse Psychotropic Drug Effects: Assessment, Implications, and Management

Joseph F. Goldberg, Carrie L. Ernst

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Adverse effects from psychiatric drugs can profoundly influence treatment adherence and outcomes. Good care involves addressing adverse effects no differently than any other component of treatment. Knowledge about adverse effect assessment and management fosters a proper context that helps clinicians not sacrifice a drug's potential therapeutic benefits because of greater concerns about its tolerability. This article provides an overview of basic concepts related to the assessment and management of suspected adverse effects from psychotropic drugs. Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.

Original language	English
Pages (from-to)	375-389
Number of pages	15
Journal	Psychiatric Clinics of North America
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/j.psc.2016.04.001
State	Published - 1 Sep 2016

Keywords

Adverse effects
Adverse event
Drug safety
Drug tolerability
Iatrogenic
Nocebo
Pharmacogenetics

Access to Document

10.1016/j.psc.2016.04.001

Cite this

@article{cb5658e2a43e418e8c2e4b8969aca3cc,

title = "Core Concepts Involving Adverse Psychotropic Drug Effects: Assessment, Implications, and Management",

abstract = "Adverse effects from psychiatric drugs can profoundly influence treatment adherence and outcomes. Good care involves addressing adverse effects no differently than any other component of treatment. Knowledge about adverse effect assessment and management fosters a proper context that helps clinicians not sacrifice a drug's potential therapeutic benefits because of greater concerns about its tolerability. This article provides an overview of basic concepts related to the assessment and management of suspected adverse effects from psychotropic drugs. Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.",

keywords = "Adverse effects, Adverse event, Drug safety, Drug tolerability, Iatrogenic, Nocebo, Pharmacogenetics",

author = "Goldberg, {Joseph F.} and Ernst, {Carrie L.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.psc.2016.04.001",

language = "English",

volume = "39",

pages = "375--389",

journal = "Psychiatric Clinics of North America",

issn = "0193-953X",

publisher = "W.B. Saunders",

number = "3",

}

TY - JOUR

T1 - Core Concepts Involving Adverse Psychotropic Drug Effects

T2 - Assessment, Implications, and Management

AU - Goldberg, Joseph F.

AU - Ernst, Carrie L.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Adverse effects from psychiatric drugs can profoundly influence treatment adherence and outcomes. Good care involves addressing adverse effects no differently than any other component of treatment. Knowledge about adverse effect assessment and management fosters a proper context that helps clinicians not sacrifice a drug's potential therapeutic benefits because of greater concerns about its tolerability. This article provides an overview of basic concepts related to the assessment and management of suspected adverse effects from psychotropic drugs. Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.

AB - Adverse effects from psychiatric drugs can profoundly influence treatment adherence and outcomes. Good care involves addressing adverse effects no differently than any other component of treatment. Knowledge about adverse effect assessment and management fosters a proper context that helps clinicians not sacrifice a drug's potential therapeutic benefits because of greater concerns about its tolerability. This article provides an overview of basic concepts related to the assessment and management of suspected adverse effects from psychotropic drugs. Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.

KW - Adverse effects

KW - Adverse event

KW - Drug safety

KW - Drug tolerability

KW - Iatrogenic

KW - Nocebo

KW - Pharmacogenetics

UR - http://www.scopus.com/inward/record.url?scp=84977589154&partnerID=8YFLogxK

U2 - 10.1016/j.psc.2016.04.001

DO - 10.1016/j.psc.2016.04.001

M3 - Review article

C2 - 27514295

AN - SCOPUS:84977589154

SN - 0193-953X

VL - 39

SP - 375

EP - 389

JO - Psychiatric Clinics of North America

JF - Psychiatric Clinics of North America

IS - 3

ER -

Core Concepts Involving Adverse Psychotropic Drug Effects: Assessment, Implications, and Management

Abstract

Keywords

Access to Document

Fingerprint

Cite this