Core Concepts Involving Adverse Psychotropic Drug Effects: Assessment, Implications, and Management

Joseph F. Goldberg, Carrie L. Ernst

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Adverse effects from psychiatric drugs can profoundly influence treatment adherence and outcomes. Good care involves addressing adverse effects no differently than any other component of treatment. Knowledge about adverse effect assessment and management fosters a proper context that helps clinicians not sacrifice a drug's potential therapeutic benefits because of greater concerns about its tolerability. This article provides an overview of basic concepts related to the assessment and management of suspected adverse effects from psychotropic drugs. Key points are discussed regarding clinical, pharmacogenetic, pharmacokinetic, and pharmacodynamic risk factors for treatment-emergent adverse effects, alongside recommendations for their systematic assessment.

Original languageEnglish
Pages (from-to)375-389
Number of pages15
JournalPsychiatric Clinics of North America
Volume39
Issue number3
DOIs
StatePublished - 1 Sep 2016

Keywords

  • Adverse effects
  • Adverse event
  • Drug safety
  • Drug tolerability
  • Iatrogenic
  • Nocebo
  • Pharmacogenetics

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