Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization

Shiv Dhiman; Hitesh Kumar Saini; Nitesh Kumar Nandwana; Dalip Kumar; Anil Kumar

doi:10.1039/c6ra03798d

Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization

Shiv Dhiman, Hitesh Kumar Saini, Nitesh Kumar Nandwana, Dalip Kumar, Anil Kumar

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.

Original language	English
Pages (from-to)	23987-23994
Number of pages	8
Journal	RSC Advances
Volume	6
Issue number	29
DOIs	https://doi.org/10.1039/c6ra03798d
State	Published - 2016
Externally published	Yes

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title = "Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization",

abstract = "A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.",

author = "Shiv Dhiman and Saini, \{Hitesh Kumar\} and Nandwana, \{Nitesh Kumar\} and Dalip Kumar and Anil Kumar",

note = "Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6ra03798d",

language = "English",

volume = "6",

pages = "23987--23994",

journal = "RSC Advances",

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T1 - Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization

AU - Dhiman, Shiv

AU - Saini, Hitesh Kumar

AU - Nandwana, Nitesh Kumar

AU - Kumar, Dalip

AU - Kumar, Anil

PY - 2016

Y1 - 2016

N2 - A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.

AB - A novel regioselective synthesis of 2-aminoquinolines and 2-arylquinoline-3-carbonitriles is described via copper-mediated tandem reaction. Formation of substituted quinolines involves Knoevenagel condensation of ortho-bromobenzaldehyde with active methylene nitriles followed by copper-catalyzed reductive amination and intramolecular cyclization.

UR - https://www.scopus.com/pages/publications/84960193520

U2 - 10.1039/c6ra03798d

DO - 10.1039/c6ra03798d

M3 - Article

AN - SCOPUS:84960193520

SN - 2046-2069

VL - 6

SP - 23987

EP - 23994

JO - RSC Advances

JF - RSC Advances

IS - 29

ER -

Copper-catalyzed synthesis of quinoline derivatives via tandem Knoevenagel condensation, amination and cyclization

Abstract

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