Coordinate and Independent Effects of Cocaine, Alcohol, and Morphine on Accumulation of IgG Aggregates in the Rat Glomeruli

Calvin Q. Pan, Pravin C. Singhal

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Focal glomerulosclerosis is the predominant glomerular lesion in patients with drug addiction. Since mesangial expansion has been considered a precursor of glomerulosclerosis we investigated whether the use of these drugs can cause accumulation of macromolecules into mesangium which may contribute to the expansion of mesangium. The majority of drug addicts at times take drugs in groups and may thus be exposed to a variety of drugs (cocaine, alcohol, and heroin). Therefore, we studied the effect of cocaine, alcohol, and morphine alone or in combination on the accumulation of radiolabeled human immunoglobulin-G (IgG) aggregates (AHIgG125l) into glomeruli/mesangium. Cocaine enhanced accumulation of AHIgG125l at 8 hr. Glomerular levels of AHIgG125l levels were also higher in morphine treated rats when compared with untreated animals. Alcohol did not alter the deposition of AHIgG125l. But at an earlier time (4 hr) alcohol enhanced the effect of cocaine on accumulation of IgG aggregates into the mesangium. The combined effects of morphine and cocaine, or morphine and alcohol were not different than the effect of morphine alone. The enhanced accumulation of phlogogenic macromolecules into the mesangium may not only increase the quantity of mesangial matrix but may also alter the quality of matrix. This may be playing an important role in the development of glomerular injury.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalExperimental Biology and Medicine
Volume205
Issue number1
DOIs
StatePublished - Jan 1994
Externally publishedYes

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