Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate.

R. S. Rosenfeld, B. Zumoff, L. Hellman

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11 Scopus citations

Abstract

Cholesterol-3-(3)H,4-(14)C was injected intravenously in man and its transformation to cholestanol was studied. From the (3)H: (14)C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained. In a second subject given cholestanol-3-(3)H,4-(14)C the (3)H: (14)C ratios in blood sterols remained unchanged for as long as 1 wk after the injection, which showed that cholestanol did not lose tritium by interconversion with cholestanone.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalJournal of Lipid Research
Volume8
Issue number1
StatePublished - Jan 1967
Externally publishedYes

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