Convergence of spectrums: neuronal gene network states in autism spectrum disorder

Josefa M. Sullivan, Silvia De Rubeis, Anne Schaefer

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by social deficits and restrictive and/or repetitive behaviors. The breadth of ASD symptoms is paralleled by the multiplicity of genes that have been implicated in its etiology. Initial findings revealed numerous ASD risk genes that contribute to synaptic function. More recently, genomic and gene expression studies point to altered chromatin function and impaired transcriptional control as additional risk factors for ASD. The consequences of impaired transcriptional alterations in ASD involve consistent changes in synaptic gene expression and cortical neuron specification during brain development. The multiplicity of genetic and environmental factors associated with ASD risk and their convergence onto common molecular pathways in neurons point to ASD as a disorder of gene regulatory networks.

Original languageEnglish
Pages (from-to)102-111
Number of pages10
JournalCurrent Opinion in Neurobiology
Volume59
DOIs
StatePublished - Dec 2019

Fingerprint

Dive into the research topics of 'Convergence of spectrums: neuronal gene network states in autism spectrum disorder'. Together they form a unique fingerprint.

Cite this